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Our manuscript was presented at the XIII Congress of the Spanish Society of Thoracic Surgery (SECT) on May 23, 2023. The presentation was well-received and was honored with one of the awards for the best scientific communication at the conference. Additionally, we have not submitted an abstract of this manuscript to the European Association for Cardio-Thoracic Surgery (EACTS) or European Society of Thoracic Surgeons (ESTS) annual meetings, as our focus was primarily on the national conference. During the preparation of this work, the authors used generative pre-trained transformer 4 (GPT-4) in order to check grammar, translation and spelling. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. Funding: All costs related to the start-up and maintenance of the GEVATS database were covered by Ethicon, Johnson & Johnson. The authors had freedom of investigation and full control of the design of the study, methods used, outcome parameters and results, data analysis, and production of the written report. The GEVATS was awarded a grant from the Spanish Society of Thoracic Surgery as the best national research project of 2015.

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Impact of radiological follow-up frequency on resected lung cancer: a propensity score matching analysis

Publicado en:Journal of Thoracic Disease. 16 (7): - 2024-07-01 16(7), DOI: 10.21037/jtd-23-1973

Autores: Fuentes-Martin, Alvaro; Martinez-Hernandez, Nestor J; Sanchez, Alberto Cabanero; Almanzar, Santiago Figueroa; Call, Sergi; Bolufer, Sergio; de Antonio, David Gomez; Moreno, Maria Fe Munoz; Embun, Raul; Ramos, Angel Cilleruelo

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Background: Despite advances in lung cancer treatment and the subsequent improvement in oncological outcomes, the optimal frequency of radiological follow-up remains unclear. Current recommendations lack consensus and do not consider individual patient characteristics and tumor factors. This study aimed to examine the impact of radiological follow-up frequency on oncological outcomes following lung cancer resection. Methods: A prospective multicenter study, involving patients who underwent anatomical lung resection in the GEVATS database between December 2016 and March 2018. The relationship between surveillance frequency and oncological outcomes was evaluated. Two groups were established based on follow-up frequency: low frequency (LF) and high frequency (HF). Subgroup analyses were performed based on tumor stage, histology, lymphadenectomy, and adjuvant therapy. Propensity score matching (PSM) was applied to balance the groups. Results: A total of 1,916 patients were included in the study, LF 444 (23.17%), HF 1,472 (76.83%). Factors associated with HF surveillance included higher stage, adjuvant chemotherapy and adjuvant radiotherapy. Subanalyses were performed after PSM for various factors, revealing significant differences between LF and HF groups in cancer-specific survival among who received adjuvant therapy {LF 53.021 months [95% confidence interval (CI): 48.622-57.421] vs. HF 58.836 months (95% CI: 55.343-62.330); HR 0.453, 95% CI: 0.242-0.849; P=0.013}, as well as overall survival for patients with squamous cell carcinoma [LF 54.394 months (95% CI: 51.424-57.364) vs. HF 61.578 months (95% CI: 59.091-64.065); HR 0.491, 95% CI: 0.299-0.806; P=0.005] and those who received adjuvant therapy LF 50.176 months [95% CI: 45.609- 54.742) vs. HF 57.189 months (95% CI: 53.599-60.778); HR 0.503, 95% CI: 0.293-0.865; P=0.013]. Conclusions: Findings suggest that high-frequency surveillance only improves survival outcomes in lung cancer patients who received adjuvant treatment or had squamous cell carcinoma. Therefore, future guidelines for lung cancer follow-up should consider individualizing the frequency of radiological surveillance based on patients' risk profiles.

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