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This research was funded by the Ministry of Science, Innovation and Universities of Spain (MICINN) and the European Regional Development Fund FEDER, grant number RTI2018-095166-B-I00. supported through, as well as Comunidad de Madrid (B-2017/BMD-3751 NOVELREN-CM and Ref. S2017/BMD3684 MOIR-2) and Instituto de Salud Carlos III, European FEDER (grant number FIS-PI19/00166) and CIBEROBN. LMM is recipient of MCINN FPU grant (FPU19/05505).

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Unveiling Metabolic Phenotype Alterations in Anorexia Nervosa through Metabolomics

Publicado en:Nutrients. 13 (12): 4249- - 2021-12-01 13(12), DOI: 10.3390/nu13124249

Autores: Mayo-Martinez, Laura; Ruperez, Francisco J.; Martos-Moreno, Gabriel A.; Graell, Montserrat; Barbas, Coral; Argente, Jesus; Garcia, Antonia;

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Anorexia nervosa (AN) is a mental disorder characterized by an intense fear of weight gain that affects mainly young women. It courses with a negative body image leading to altered eating behaviors that have devastating physical, metabolic, and psychological consequences for the patients. Although its origin is postulated to be multifactorial, the etiology of AN remains unknown, and this increases the likelihood of chronification and relapsing. Thus, expanding the available knowledge on the pathophysiology of AN is of enormous interest. Metabolomics is proposed as a powerful tool for the elucidation of disease mechanisms and to provide new insights into the diagnosis, treatment, and prognosis of AN. A review of the literature related to studies of AN patients by employing metabolomic strategies to characterize the main alterations associated with the metabolic phenotype of AN during the last 10 years is described. The most common metabolic alterations are derived from chronic starvation, including amino acid, lipid, and carbohydrate disturbances. Nonetheless, recent findings have shifted the attention to gut-microbiota metabolites as possible factors contributing to AN development, progression, and maintenance. We have identified the areas of ongoing research in AN and propose further perspectives to improve our knowledge and understanding of this disease.

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