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Rodriguez Artalejo, FernandoAutor o CoautorGarcia Garcia-Esquinas, EstherAutor o CoautorBosch Esteva, Orencio FranciscoAutor o CoautorChaparro M.Autor o CoautorMartín-Arranz M.d.Autor o CoautorPerez Gisbert, Francisco JavierAutor o Coautor

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Incidence, clinical characteristics and management of inflammatory bowel disease in spain: Large-scale epidemiological study

Publicado en:Journal of Clinical Medicine. 10 (13): 2885- - 2021-07-01 10(13), DOI: 10.3390/jcm10132885

Autores: Chaparro, Maria; Garre, Ana; Nunez Ortiz, Andrea; Diz-Lois Palomares, Maria Teresa; Rodriguez, Cristina; Riestra, Sabino; Vela, Milagros; Manuel Benitez, Jose; Fernandez Salgado, Estela; Sanchez Rodriguez, Eugenia; Hernandez, Vicent; Ferreiro-Iglesias, Rocio; Diaz, Angel Ponferrada; Barrio, Jesus; Maria Huguet, Jose; Sicilia, Beatriz; Dolores Martin-Arranz, Maria; Calvet, Xavier; Ginard, Daniel; Alonso-Abreu, Inmaculada; Fernandez-Salazar, Luis; Varela Trastoy, Pilar; Rivero, Montserrat; Vera-Mendoza, Isabel; Vega, Pablo; Navarro, Pablo; Sierra, Monica; Luis Cabriada, Jose; Aguas, Mariam; Vicente, Raquel; Navarro-Llavat, Merce; Echarri, Ana; Gomollon, Fernando; Guerra del Rio, Elena; Pinero, Concepcion; Jose Casanova, Maria; Spicakova, Katerina; Ortiz de Zarate, Jone; Torrella Cortes, Emilio; Gutierrez, Ana; Alonso-Galan, Horacio; Hernandez-Martinez, Alvaro; Miguel Marrero, Jose; Lorente Poyatos, Rufo; Calafat, Margalida; Marti Romero, Lidia; Robledo, Pilar; Bosch, Orencio; Jimenez, Nuria; Esteve Comas, Maria; Maria Duque, Jose; Fuentes Coronel, Ana Maria; Josefa Sampedro, Manuela; Sese Abizanda, Eva; Herreros Martinez, Belen; Pozzati, Liliana; Fernandez Rosaenz, Hipolito; Crespo Suarez, Belen; Lopez Serrano, Pilar; Lucendo, Alfredo J; Munoz Vicente, Margarita; Bermejo, Fernando; Ramirez Palanca, Jose Joaquin; Menacho, Margarita; Carmona, Amalia; Camargo, Raquel; Torra Alsina, Sandra; Maroto, Nuria; Nerin de la Puerta, Juan; Castro, Elena; Marin-Jimenez, Ignacio; Botella, Belen; Sapina, Amparo; Cruz, Noelia; Forcelledo, Jose Luis F; Bouhmidi, Abdel; Castano-Milla, Carlos; Opio, Veronica; Nicolas, Isabel; Kutz, Marcos; Abraldes Bechiarelli, Alfredo; Gordillo, Jordi; Ber, Yolanda; Torres Dominguez, Yolanda; Novella Duran, Maria Teresa; Rodriguez Mondejar, Silvia; Martinez-Cerezo, Francisco J; Kolle, Lilyan; Sabat, Miriam; Ledezma, Cesar; Iyo, Eduardo; Roncero, Oscar; Irisarri, Rebeca; Lluis, Laia; Blazquez Gomez, Isabel; Maria Zapata, Eva; Jose Alcala, Maria; Martinez Pascual, Cristina; Montealegre, Maria; Mata, Laura; Monrobel, Ana; Hernandez Camba, Alejandro; Hernandez, Luis; Tejada, Maria; Mir, Alberto; Luisa Galve, Maria; Soler, Marta; Hervias, Daniel; Antonio Gomez-Valero, Jose; Barreiro-de Acosta, Manuel; Rodriguez-Artalejo, Fernando; Garcia-Esquinas, Esther; Gisbert, Javier P

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Resumen

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD—Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)—during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31–56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.

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