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Citations

563

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Grant support

This study was supported by Ministerio de Economia, Competitividad e Industria (MINECO) grants SAF2015-65607 and SAF2013-49662-EXP to A. Hidalgo; SVP-2014-068595 to J.A. Nicolas-Avila; BES-2013-065550 to J.M. Adrover; JCI-2012-12659 to N. A-Gonzalez; and SAF2014-56819-R and SAF-2015-71878-REDT to A. Castrillo. Grant CAM S2010/BMD-2350 RAPHYME to A. Castrillo; SAF2015-64287-R, SAF2015-71878-REDT (MINECO), and CardioNext-ITN-608027 (European Commission FP7) to M. Ricote; and R01 AI089824 (National Institutes of Health) to C.V. Rothlin. H.P. is supported by grants from MINECO (SAF2014-54541-R), ATRESMEDIA - AXA, Asociacion Espanola Contra el Cancer, WHRI Academy, and Worldwide Cancer Research. The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) is supported by the MINECO and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).

Analysis of institutional authors

Gonzalez De La Aleja, ArturoAuthor

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Article

Phagocytosis imprints heterogeneity in tissue-resident macrophages

Publicated to:JOURNAL OF EXPERIMENTAL MEDICINE. 214 (5): 1281-1296 - 2017-05-01 214(5), DOI: 10.1084/jem.20161375

Authors: A-Gonzalez, Noelia; Quintana, Juan A; Garcia-Silva, Susana; Mazariegos, Marina; Gonzalez de la Aleja, Arturo; Nicolas-Avila, Jose A; Walter, Wencke; Adrover, Jose M; Crainiciuc, Georgiana; Kuchroo, Vijay K; Rothlin, Carla V; Peinado, Hector; Castrillo, Antonio; Ricote, Mercedes; Hidalgo, Andres

Affiliations

Brigham & Womens Hosp, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA - Author
Ctr Nacl Invest Cardiovasc Carlos III, Area Cell & Dev Biol, Madrid 28029, Spain - Author
Ctr Nacl Invest Cardiovasc Carlos III, Area Myocardial Pathophysiol, Madrid 28029, Spain - Author
Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, D-80539 Munich, Germany - Author
Spanish Natl Canc Res Ctr, Mol Oncol Program, Microenvironm & Metastasis Grp, Madrid 28029, Spain - Author
Univ Las Palmas Gran Canaria, Inst Univ Invest Biomed & Sanitarias, CSIC Madrid, Inst Invest Biomed Alberto Sols,Unidad Asociada, Las Palmas Gran Canaria 35001, Spain - Author
Yale Sch Med, Immunobiol Dept, New Haven, CT 06510 USA - Author
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Abstract

Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.

Keywords

Activated receptor-gammaApoptotic cellsClearanceDifferentiationEngulfmentEpithelial-cellsGene-expressionInductionPpar-gammaTgf-beta

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF EXPERIMENTAL MEDICINE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 6/133, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, Research & Experimental. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 9.21. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-01, the following number of citations:

  • WoS: 197
  • Scopus: 213
  • Europe PMC: 153

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 414.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 415 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 107.25.
  • The number of mentions on the social network Facebook: 2 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 35 (Altmetric).
  • The number of mentions in news outlets: 12 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Germany; United States of America.