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Article

Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity

Publicated to:J Pers Med. 12 (6): 894- - 2022-06-01 12(6), DOI: 10.3390/jpm12060894

Authors: Garcia-Mesa, Yolanda; Martin-Sanz, Raquel; Garcia-Piqueras, Jorge; Cobo, Ramon; Munoz-Bravo, Saray; Garcia-Suarez, Olivia; Martin-Biedma, Benjamin; Vega, Jose Antonio; Feito, Jorge

Affiliations

Complejo Asistencial Univ Salamanca, Inst Invest Biomed Salamanca, Serv Anat Patol, Salamanca 37007, Spain - Author
Complejo Asistencial Univ Salamanca, Serv Oftalmol, IBSAL, Salamanca 37007, Spain - Author
Instituto de Investigación Biomédica de Salamanca (IBSAL) - Author
Univ Autonoma Chile, Fac Ciencias Salud, Santiago 7500912, Chile - Author
Univ Oviedo, Grp SINPOS, Dept Morfol & Biol Celular, Oviedo 33003, Spain - Author
Univ Santiago de Compostela, Dept Cirugia & Especialidades Medicoquirurg, Santiago De Compostela 15782, Spain - Author
Univ Zaragoza, Dept Anat & Histol, Zaragoza 50009, Spain - Author
Universidad Autónoma de Chile , Universidad de Oviedo - Author
Universidad de Oviedo - Author
Universidad de Santiago de Compostela - Author
Universidad de Zaragoza , Universidad de Oviedo - Author
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Abstract

As an essential component of mechano-gated ion channels, critically required for mecha-notransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we immunohistochemically investigated the occurrence of Piezo channels in a case series of Merkel cell carcinoma. A panel of antibodies was used to characterize Merkel cells, and to detect PIEZO2 expression. All analyzed tumors displayed PIEZO2 in nearly all cells, showing two patterns of immunostaining: membranous and perinuclear dot-like. PIEZO2 co-local-ized with cytokeratin 20, chromogranin A, synaptophysin and neurofilament. Moreover, neurofil-ament immunoreactive structures resembling nerve-Merkel cell contacts were occasionally found. PIEZO2 was also detected in cells of the sweat ducts. The role of PIEZO2 in Merkel cell carcinoma is still unknown, but it could be related with the mechanical regulation of the tumor biology or be a mere vestige of the Merkel cell derivation.

Keywords
cancer mechanobiologyion channelsmechanobiologymerkel cell carcinomapiezo2proteinsCancer mechanobiologyIon channelsMechanobiologyMerkel cell carcinomaMerkel cellsPiezo2Touch

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal J Pers Med due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 67/169, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine, General & Internal. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.14, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 1.5 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-19, the following number of citations:

  • WoS: 3
  • Scopus: 5
  • Europe PMC: 3
  • OpenCitations: 4
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-19:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 10 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile.