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This study was funded by Consejeria de Salud y Familias, Junta de Andalucia (PI-0247-2016) and Instituto de Salud Carlos III, Ministerio de Sanidad, Gobierno de Espana, (PI17/01004). FJBS, GRM and REB belong to the regional "Nicolas Monardes" research program from Consejeria de Salud, Junta de Andalucia, Spain (C-0070-2012, C-0060-2012 and C-0030-2016). IRG holds a Rio Hortega contract from Instituto de Salud Carlos III (CM20/00225) cofunded by Euro-pean Social Fund 2014-2020, EU "The ESF invests in your future". CIBERDEM is an initiative of the Instituto de Salud Carlos III, EU. Funding for Open Access charge: Universidad de Malaga/CBUA.

Analysis of institutional authors

Ruiz-Garcia, IgnacioAuthor
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Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study

Publicated to:CLINICAL NUTRITION. 42 (8): 1389-1398 - 2023-08-01 42(8), DOI: 10.1016/j.clnu.2023.06.027

Authors: Ruiz-García, I; Ortíz-Flores, R; Badía, R; García-Borrego, A; García-Fernández, M; Lara, E; Martín-Montañez, E; García-Serrano, S; Valdés, S; Gonzalo, M; Tapia-Guerrero, SMJ; Fernandez-García, JC; Sánchez-García, A; Muñoz-Cobos, F; Calderón-Cid, M; El-Bekay, R; Covas, MI; Rojo-Martínez, G; Olveira, G; Romero-Zerbo, SY; Bermúdez-Silva, FJ

Affiliations

CSIC, Inst Grasa, Dept Fitoquim Alimentos, Seville, Spain - Author
Hosp Quironsalud, Marbella, Spain - Author
Hosp Reg Univ Malaga, CIBER Diabet & Enfermedades Metab Asociadas CIBERD, Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Plataforma BIONAND,UGC Endocrinol & Nutr, Malaga, Spain - Author
Junta Andalucia, Ctr Salud El Palo, Consejeria Salud & Familias, Malaga, Spain - Author
Nuproas HB, Stockholm, Sweden - Author
Univ Malaga, Fac Med, Dept Farmacol, Malaga, Spain - Author
Univ Malaga, Fac Med, Dept Fisiol Humana, Malaga, Spain - Author
Univ Malaga, Fac Med, Dept Med & Dermatol, Malaga, Spain - Author
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Abstract

Background: Oleocanthal and oleacein are olive oil phenolic compounds with well known antiinflammatory and anti-oxidant properties. The main evidence, however, is provided by experimental studies. Few human studies have examined the health benefits of olive oils rich in these biophenols. Our aim was to assess the health properties of rich oleocanthal and oleacein extra virgin olive oil (EVOO), compared to those of common olive oil (OO), in people with prediabetes and obesity. Methods: Randomised, double-blind, crossover trial done in people aged 40-65 years with obesity (BMI 30-40 kg/m2) and prediabetes (HbA1c 5.7-6.4%). The intervention consisted in substituting for 1 month the oil used for food, both raw and cooked, by EVOO or OO. No changes in diet or physical activity were recommended. The primary outcome was the inflammatory status. Secondary outcomes were the oxidative status, body weight, glucose handling and lipid profile. An ANCOVA model adjusted for age, sex and treatment administration sequence was used for the statistical analysis. Results: A total of 91 patients were enrolled (33 men and 58 women) and finished the trial. A decrease in interferon-g was observed after EVOO treatment, reaching inter-treatment differences (P 1/4 0.041). Total antioxidant status increased and lipid and organic peroxides decreased after EVOO treatment, the changes reaching significance compared to OO treatment (P < 0.05). Decreases in weight, BMI and blood glucose (p < 0.05) were found after treatment with EVOO and not with OO. Conclusions: Treatment with EVOO rich in oleocanthal and oleacein differentially improved oxidative and inflammatory status in people with obesity and prediabetes. & COPY; 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Keywords
inflammationobesityoleaceinoleocanthalolive oilIn flammationObesityOleaceinOleocanthalOlive oilPrediabetes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal CLINICAL NUTRITION due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 10/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 12.73, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-11, the following number of citations:

  • WoS: 1
  • Scopus: 16
  • OpenCitations: 12
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-11:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 105.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 103 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 237.4.
  • The number of mentions on the social network X (formerly Twitter): 27 (Altmetric).
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Sweden.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (RUIZ GARCIA, IGNACIO) .