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Otero Gómez AAuthor

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July 3, 2023
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Deletion of exon b3 of the BCR gene in CML: Easy breakpoint mapping by a two-round PCR

Publicated to:CANCER GENETICS AND CYTOGENETICS. 91 (1): 71-73 - 1996-10-01 91(1), DOI: 10.1016/S0165-4608(96)00111-2

Authors: Cigudosa JC; Acosta Almeida MT; Carrasco Juan JL; Otero Gómez A; Hernández Nieto L; García Talavera J; García Miranda JL

Affiliations

Facultad de Ciencias de la Salud , Universidad de la Laguna - Author
Hospital Universitario de Canarias - Author
Hospital Universitario Nuestra Senora de Candelaria - Author
Universidad de la Laguna - Author

Abstract

We have performed the molecular analysis for the detection of the BCR- ABL and ABL-BCR fusion genes in 50 patients with myeloproliferative disorders. All patients diagnosed with CML (13 out of 50) were positive for the BCR-ABL hybrid. Six CML patients (46%) showed ABL-BCR amplifications of the Ib-BCR type. All rearrangements but one were concordant. The aberrant case presented a deletion of exon b3, in addition to the alternative Ib-BCR and Ia-BCR. Its possible origin and relevance are briefly discussed.

Keywords

BiodiversidadeBiotecnologíaCancer researchCiências biológicas iCiências biológicas iiCiências biológicas iiiGeneticsGenetics & heredityInterdisciplinarMedicina iMedicina iiMedicina iiiMolecular biologyOdontologíaOncologySaúde coletiva

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-18:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 41% according to the mBERT algorithm developed by Aurora University.