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Grant support

We thank the Wellcome Trust Sanger Institute sequencing and informatics teams for support. This project was funded by the Wellcome Trust, United Kingdom (grant 051087/Z97/Z) and the Spanish Ministry of Economy and Competitiviness (grants SAF2009-07857 and SAF2012-38957). A.L-B. and CM. were recipients of a Ramon y Cajal Fellowship and a Formacion del Personal Investigador Ph.D. Studentship, respectively, from the Spanish Ministry of Economy and Competitiviness.

Analysis of institutional authors

Lopez-Bueno, AlbertoAuthor

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Article

The genome sequence of ectromelia virus Naval and Cornell isolates from outbreaks in North America

Publicated to:VIROLOGY. 462 (1): 218-226 - 2014-01-01 462(1), DOI: 10.1016/j.virol.2014.06.010

Authors: Mavian, Carla; Lopez-Bueno, Alberto; Bryant, Neil A.; Seeger, Kathy; Quail, Michael A.; Harris, David; Barrell, Bart; Alcami, Antonio;

Affiliations

Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Nicolas Cabrera 1, Campus de Cantoblanco, Madrid, Spain - Author
Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), Nicolas Cabrera 1, Campus de Cantoblanco, Madrid, Spain. - Author
Department of Medicine, University of Cambridge, United Kingdom. - Author
Department of Medicine, University of Cambridge, United Kingdom. Electronic address: aalcami@cbm.csic.es. - Author
Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain - Author
Univ Cambridge, Dept Med, Cambridge CB2 1TN, England - Author
Wellcome Trust Sanger Inst, Hinxton, England - Author
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, United Kingdom. - Author
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Abstract

Ectromelia virus (ECTV) is the causative agent of mousepox, a disease of laboratory mouse colonies and an excellent model for human smallpox. We report the genome sequence of two isolates from outbreaks in laboratory mouse colonies in the USA in 1995 and 1999: ECTV-Naval and ECTV-Cornell, respectively. The genome of ECTV-Naval and ECTV-Cornell was sequenced by the 454-Roche technology. The ECTV-Naval genome was also sequenced by the Sanger and Illumina technologies in order to evaluate these technologies for poxvirus genome sequencing. Genomic comparisons revealed that ECTV-Naval and ECTV-Cornell correspond to the same virus isolated from independent outbreaks. Both ECTV-Naval and ECTV-Cornell are extremely virulent in susceptible BALB/c mice, similar to ECTV-Moscow. This is consistent with the ECTV-Naval genome sharing 98.2% DNA sequence identity with that of ECTV-Moscow, and indicates that the genetic differences with ECTV-Moscow do not affect the virulence of ECTV-Naval in the mousepox model of footpad infection. (C) 2014 The Authors. Published by Elsevier Inc.

Keywords

ectromelia virusgenome sequencepoxvirusA-type inclusionBinding-proteinCausative agentChemokine activityEctromelia virusGenome sequenceInfectious ectromeliaInhibitionMousepoxPoxvirusSt-louisSuperoxide-dismutaseVaccinia virusVirulence

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal VIROLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Virology.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.1, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-30, the following number of citations:

  • WoS: 21
  • Scopus: 24
  • Europe PMC: 21

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-30:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mavian, Carla) and Last Author (Alcami, Antonio).

the author responsible for correspondence tasks has been Alcami, Antonio.