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Llamas-Velasco, MarAuthor

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Review

Biological Treatments in Atopic Dermatitis

Publicated to:Journal of Clinical Medicine. 4 (4): 593-613 - 2015-04-01 4(4), DOI: 10.3390/jcm4040593

Authors: Montes-Torres, Andrea; Llamas-Velasco, Mar; Perez-Plaza, Alejandra; Solano-Lopez, Guillermo; Sanchez-Perez, Javier;

Affiliations

Hosp Univ La Princesa, Dept Dermatol, Diego de Leon 62, Madrid 28006, Spain - Author

Abstract

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases that affect both children and adults with a prevalence of 30% and 10%, respectively. Even though most of patients respond satisfactory to topical anti-inflammatory drugs, about 10% require one or more systemic treatments to achieve good control of their illness. The progressive and increasingly detailed knowledge in the immunopathogenesis of AD has allowed research on new therapeutic targets with very promising results in the field of biological therapy. In this article, we will review the different biological treatments with a focus on novel drugs. Their mechanism of action, current status and results from clinical trials and observational studies will be specified.

Keywords

antibody therapyatopic dermatitisatopic eczemabiologicsAdultAnti-cd20 rituximab treatmentAntibody therapyAtopic dermatitisAtopic eczemaBiologicsEczemaEfalizumabMast-cellsMonoclonal-antibodyOmalizumabPathogenesisReceptorT-cellsTherapy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 7.43, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-27, the following number of citations:

  • WoS: 47
  • Scopus: 56

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-27:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 98.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 98 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 10.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).