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Analysis of institutional authors

De La Fuente HAuthorCibrian DAuthorSanchez-Madrid FAuthor

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April 3, 2023
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UNRAVELING CD69 SIGNALING PATHWAYS, LIGANDS AND LATERALLY ASSOCIATED MOLECULES

Publicated to:EXCLI Journal. 22 334-351 - 2023-01-01 22(), DOI: 10.17179/excli2023-5751

Authors: Jimenez-Fernandez, Maria; de la Fuente, Hortensia; Martin, Pilar; Cibrian, Danay; Sanchez-Madrid, Francisco

Affiliations

Centro de Investigación en Red en Enfermedades Cardiovasculares , Centro Nacional de Investigaciones Cardiovasculares Carlos III - Author
Ctr Nacl Invest Cardiovasc CNIC, Madrid 29029, Spain - Author
Inst Salud Carlos III, CIBER Enfermedades Cardiovasc CIBERCV, Madrid 28029, Spain - Author
Instituto de Investigación Sanitaria Hospital Universitario de La Princesa , Centro de Investigación en Red en Enfermedades Cardiovasculares , Centro Nacional de Investigaciones Cardiovasculares Carlos III - Author
Instituto de Investigación Sanitaria Hospital Universitario de La Princesa , Centro Nacional de Investigaciones Cardiovasculares Carlos III - Author
Univ Autonoma Madrid UAM, Hosp Univ La Princesa, Inst Invest Sanitaria Hosp Univ Princesa IIS IP, Madrid 28006, Spain - Author
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Abstract

CD69 is an early leukocyte activation marker involved in the regulation of the immune response. Initial in vitro studies evaluated its function using monoclonal antibodies until knock-out mice were developed. Subsequently, four ligands for CD69 have been identified, namely galectin-1, S100A8/S100A9 complex, myosin light chains 9 and 12, and oxidized low-density lipoproteins. In addition, several molecules are laterally associated with and regulated by CD69, including calreticulin and two transmembrane receptors, sphingosine-1-phosphate receptor (S1P1) and the heterodimeric amino acid transporter complex SLC7A5-SLC3A2 (LAT1-CD98). Recently, CD69 engagement has been shown to induce the expression of the immunoregulatory receptor programmed cell death-1 (PD-1) in T cells. The molecular signaling induced by CD69 has been explored in different scenarios and cell types. This review provides a perspective on the molecular pathways, ligands and cellular functions known to be regulated by CD69.

Keywords

Cd69Cd69-ligandsCd69-signalingMolecular signaling-pathway

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EXCLI Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 18/109, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-22:

  • Scopus: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-22:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 29 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Jiménez-Fernández M) and Last Author (SANCHEZ MADRID, FRANCISCO).