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Analysis of institutional authors

Garcia-Salido, AlbertoCorresponding Author

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March 20, 2023
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IgG antispike persistence and immunophenotype in children infected by SARS-CoV-2

Publicated to:ACTA PAEDIATRICA. 112 (4): 805-812 - 2023-02-17 112(4), DOI: 10.1111/apa.16705

Authors: García-Salido, A; Flores-Pérez, P; González-Murillo, A; Sánchez-Marcos, E; Leoz-Gordillo, I; Cano-Fernández, J; Castillo-Robleda, A; Nieto-Moro, M; Jiménez-García, R

Affiliations

Hosp Infantil Univ Nino Jesus, Pediat Crit Care Unit, Madrid, Spain - Author
Univ Nino Jesus, Pediat Dept, Hosp Infantil, Madrid, Spain - Author
Univ Nino Jesus, Pediat Oncohematol Unit, Flow Cytometry Lab, Hosp Infantil, Madrid, Spain - Author

Abstract

Aim: The immune status of children recovering from SARS- CoV- 2 infection is not completely understood. We describe IgG antispike persistence in children infected during the first two pandemic waves. In addition, we compared with healthy controls their leukocyte populations and CD64 expression.Methods: Cross-sectional study. Carried out from October 2021 to February 2022 in nonreinfected and nonvaccinated children with SARS- CoV- 2 in 2020. The presence of antispike IgG was studied using chemiluminescent immunoassay. Leukocyte populations were analysed using flow cytometry and marked for CD45, CD4, CD8 and CD64. Statistical minor than 0.05 was considered significant.Results: One hundred and eighty -three control and 77 patients were included. IgG antispike determinations were performed after a median of 501 days (262- 464); 52 of 77 children were positive. Cases showed significantly higher percentages of monocytes, lymphocytes, CD8(+) and CD4(+). In addition, CD64 expression was higher in monocytes and neutrophils. The presence of IgG antispike was accompanied by a higher percentage of CD64(+) neutrophils.Conclusion: In our series, the SARS- CoV- 2 IgG antispike protein was usually positive beyond 1 year after infection. Furthermore, leukocyte populations from cases differ from controls, with higher CD64 expression on neutrophils and monocytes. Prospective clinical observations are required to confirm the implications of these findings.

Keywords

cd64childrenig antispikesars-cov-2Cd64ChildrenCovid-19Ig antispikeInflammationSars-cov-2

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ACTA PAEDIATRICA due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 46/186, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pediatrics.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.05.
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (GARCIA SALIDO, ALBERTO) .

the author responsible for correspondence tasks has been GARCIA SALIDO, ALBERTO.