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Lassaletta, AlvaroCorresponding Author

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December 1, 2022
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Asparaginase activity monitoring in pediatric acute lymphoblastic leukemia: A cross-sectional nationwide study in Spain

Publicated to:Cancer Reports. 6 (2): e1729- - 2023-01-01 6(2), DOI: 10.1002/cnr2.1729

Authors: Lassaletta, Alvaro; Gutierrez, Fernando

Affiliations

Complejo Hosp Univ Canarias, Res Dept, Pharm Dept, Santa Cruz De Tenerife, Spain - Author
Hosp Infantil Univ Nino Jesus, Pediat Hematol Oncol Dept, Ave Menendez Pelayo 65, Madrid 28009, Spain - Author

Abstract

Background A cross-sectional nationwide study was designed to assess national compliance with international consensus/guidelines of monitoring asparaginase levels in children with acute lymphoblastic leukemia (ALL) treated with asparaginase in routine clinical practice. Methods An ad hoc questionnaire was designed and completed by staff physicians from Hemato-Oncology Units throughout Spain. Results A total of 39 physicians (64% pediatricians) with a mean (SD) age 43.5 (7.9) years and 15.3 (17.6) years of professional activity participated in the study. They accounted for 90% of hospitals in which children with ALL are treated in Spain. A total of 19 participants (48.7%) reported that asparaginase levels were routinely monitored (own center in 2 cases [10.5%], another hospital in 17 cases [89.5%]). Asparaginase was not monitored in 51.3% of the cases, mostly (80%) because unavailability of testing. When asparaginase was monitored, 68% of participants reported that this was done in all asparaginase-treated patients and 84% in all phases of the disease (induction, consolidation, re-induction, maintenance) with a time interval of 7 days for the pegylated form, 48 h for Erwinia asparaginase and 14 days for maintenance with the pegylated form. All participants reported that they modified treatment according to results of testing, with a limit of total depletion of >= 100 IU/L. Levels <100 or 20 IU/L were considered indicative of hypersensitivity by 46% of physicians. Conclusion There is still a gap between what is recommended and what is done in clinical practice, with more than 50% of centers not monitoring the level of asparaginase activity in pediatric ALL. Protocols for asparaginase testing in daily practice should be implemented.

Keywords

acute lymphoblastic leukemiaasparaginaseasparaginecross- sectional studyAcute lymphoblastic leukemiaAdultAsparaginaseAsparagineCancerChildChildrenCross- sectional studyCross-sectional studiesDepletionHumansLong-termPeg-asparaginasePolyethylene glycolsPrecursor cell lymphoblastic leukemia-lymphomaSpainSurvey

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cancer Reports, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Oncology, give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-02:

  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (LASSALETTA ATIENZA, ALVARO) .

    the author responsible for correspondence tasks has been LASSALETTA ATIENZA, ALVARO.