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This work was supported by ViiV Healthcare. A.E.-C. is supported by a PFIS fellowship from Instituto de Salud Carlos III-Fondo Social Europeo (FI17/00194). R.DM and J.C. are supported by a Rio Hortega fellowship from Instituto de Salud Carlos III-Fondo Social Europeo (CM17/00064 and CM19/00059).

Analysis of institutional authors

Arribas, Jose RCorresponding Author

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November 16, 2022
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Effects of tenofovir on telomeres, telomerase and T cell maturational subset distribution in long-term aviraemic HIV-infected adults

Publicated to:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 77 (4): 1125-1132 - 2022-03-31 77(4), DOI: 10.1093/jac/dkab492

Authors: Rodriguez-Centeno, Javier; Esteban-Cantos, Andres; Montejano, Rocio; Stella-Ascariz, Natalia; De Miguel, Rosa; Mena-Garay, Beatriz; Saiz-Medrano, Gabriel; Alejos, Belen; Jimenez-Gonzalez, Maria; Bernardino, Jose, I; Cadinanos, Julen; Castro-Alvarez, Juan M.; Rodes, Berta; Arribas, Jose R.;

Affiliations

CIBER Enfermedades Infecciosas, Madrid, Spain - Author
Inst Hlth Res Hosp La Paz IdiPAZ, Madrid, Spain - Author
Inst Salud Carlos III, Madrid, Spain - Author
La Paz Univ Hosp, Internal Med Dept, Madrid, Spain - Author

Abstract

Objectives To evaluate whether the negative impact of tenofovir on telomere length (TL) is due to immune reconstitution interference or inhibition of telomerase. Methods One hundred and twenty-eight long-term aviraemic HIV adults treated with tenofovir-containing (n = 79) or tenofovir-sparing regimens (n = 49) were recruited to compare the following: TL in whole blood, PBMCs, CD4+ T cells and CD8+ T cells by quantitative PCR (qPCR); telomerase activity in PBMCs, CD4+ cells and CD8+ T cells using the TRAPeze RT Telomerase Detection Kit; and T cell maturational subset distribution by flow cytometry. Results In an adjusted analysis, participants treated with tenofovir for at least 4 years had shorter TL in CD8+ T cells (P = 0.04) and lower telomerase activity in CD4+ (P = 0.012) and CD8+ T cells (P = 0.023). Tenofovir treatment was also associated with lower proportions of recent thymic emigrant (RTE) CD4+ cells (P = 0.031) and PD1 marker expression (P = 0.013). Conclusions In long-term aviraemic HIV adults, the inhibition of telomerase by tenofovir could explain telomere shortening in CD8+ T cells. There is no telomere shortening in the CD4+ compartment and the decrease in telomerase activity could be explained both by the inhibition by tenofovir and by the lower proportion of RTE CD4+cells.

Keywords

AbacavirActivationCd4(+)EmtricitabineExpressionInflammationLengthLymphocytesMarkersTherapy

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 55/278, thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmacology & Pharmacy.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.61, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-08, the following number of citations:

  • WoS: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-08:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (ARRIBAS LOPEZ, JOSE RAMON).

the author responsible for correspondence tasks has been ARRIBAS LOPEZ, JOSE RAMON.