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Grant support

Supported by the European Research Council (ERC-CoG-2020-101001916), Spain's Ministry of Economy and Competitiveness (PID2020-113007RB-I00, SAF-2017-82185-R, and RYC-2015-171899), the Alzheimer's Association (2015-NIRG-340709, AARG-17-528125, and AARG-17-528125-RAPID), the Association for Frontotemporal Degeneration (2016 Basic Science Pilot Grant Award), and the Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED, Spain) (M.Ll.-M.); a Universidad Autonoma de Madrid doctoral fellowship (FPI-UAM 2017 program) (J.T.R.); a Fundacion Tatiana Perez de Guzman 2018 neuroscience doctoral fellowship (E.P.M.J.); a Formacion de Personal Investigador (FPI) contract, associated with grant SAF-2017-82185-R to M.Ll.-M., supported by Spain's Ministry for Economy and Competitiveness grant PRE2018-085233 (M.F.G.); Spain's Ministry of Economy and Competitiveness award "Subvenciones para la promocion de empleo joven e Implantacion de la garantia juvenil en I+D+i 2018" (PEJ2018-001725-A) and Alzheimer's Association grant AARG-17-528125-RAPID to M.Ll.-M. (C.B.R.M.); Consejo Nacional de Ciencia y Tecnologia (CONACYT) of Mexican Government (CVU 385084) and Secretaria de Educacion, Ciencia Tecnologia e Innovacion (SECTEI) de la Ciudad de Mexico (CDMX) postdoctoral fellowships (B.M.V.); and institutional grants to CBMSO from the Fundacion Ramon Areces and Banco de Santander.

Analysis of institutional authors

Llorens Martin, Maria VictoriaAuthorMarquez Valadez, BereniceAuthorTerreros-Roncal, JAuthor

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April 29, 2022
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Editorial Material

Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

Publicated to:SCIENCE. 376 (6590): eabo0920- - 2022-04-15 376(6590), DOI: 10.1126/science.abo0920

Authors: Terreros-Roncal, J; Moreno-Jimenez, E P; Flor-Garcia, M; Rodriguez-Moreno, C B; Trinchero, M F; Marquez-Valadez, B; Cafini, F; Rabano, A; Llorens-Martin, M

Affiliations

CIEN Fdn, Neuropathol Dept, Madrid, Spain - Author
Ctr Networked Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain - Author
Leloir Inst IIBBA CONICET, Lab Neuronal Plast, Buenos Aires, DF, Argentina - Author
Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa CBMSO, Dept Mol Neuropathol, Spanish Res Council CSIC, Madrid, Spain - Author
Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Dept Mol Neuropathol, Spanish Res Council CSIC, Madrid, Spain - Author
Univ Autonoma Madrid, Fac Sci, Dept Mol Biol, Madrid, Spain - Author
Univ Europea Madrid, Fac Biomed & Hlth Sci, Madrid, Spain - Author
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Abstract

Alvarez-Buylla and colleagues provide an alternative interpretation of some of the data included in our manuscript and question whether well-validated markers of adult hippocampal neurogenesis (AHN) are related to this phenomenon in our study. In Terreros-Roncal et al., reconstruction of the main stages of human AHN revealed its enhanced vulnerability to neurodegeneration. Here, we clarify ambiguities raised by these authors.

Keywords

cellsAdultDoublecortinHippocampusHumansNeurodegenerative diseasesNeurogenesis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal SCIENCE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 2/73, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.37. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 4.29 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 2.9 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-05, the following number of citations:

  • WoS: 8
  • Scopus: 9
  • Europe PMC: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 20.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 20 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (TERREROS RONCAL, JULIA) .