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CKD: The burden of disease invisible to research funders

Publicated to:NEFROLOGIA. 42 (1): 65-84 - 2022-02-01 42(1), DOI: 10.1016/j.nefro.2021.09.004

Authors: Hernandez Gallego, Roman; Martinez Jimenez, Victor; Rodriguez Perez, Jose Carlos; Furlano, Monica; Sans Atxer, Laia; Gomez Ruiz, Josefa; de Sequera Ortiz, Patricia; de Arriba de la Fuente, Gabriel; Quiroga Gili, Borja; Soriano Cabrera, Sagrario; Perez Contreras, Javier; Blasco Pelicano, Miquel; Mazuecos Blanca, Auxiliadora; Rodriguez Portillo, Mariano; Sanchez Alvarez, J Emilio; Soler Romeo, Maria Jose; Gorostidi Perez, Manuel; Goicoechea Diezhandino, Marian; Hernandez Marrero, Domingo; Fondevila Campo, Constantino; Minambres Garcia, Eduardo; Garcia-Cosio Carmona, Dolores; Torres Ramirez, Armando; Munoz Bellvis, Luis; Berenguer Haym, Marina; Barrera Gomez, Manuel; Cifrian Martinez, Jose Manuel; Cruzado Garrit, Josep Maria; San Juan Garrido, Rafael; Briceno Delgado, Javier; Bodro Marimont, Marta; Valentin Munoz, Maria O; Salvatierra Velazquez, Angel; Almenar Bonet, Luis; Gomez Bravo, Miguel Angel; Moreso Mateos, Francesc J; Muro Amador, Manuel; Pons Minano, Jose A; Andres Belmonte, Amado; Sole Jover, Amparo; Casanova Rituerto, Daniel; Pardo Sanchez, Fernando; Ortiz, Alberto; Sanz, Ana B; Ramos, Adrian M; Cordoba-David, Gina; Garcia-Jimenez, Jorge; Fontecha-Barriuso, Miguel; Guerrero-Mauvecin, Juan; Lopez-Diaz, Ana M; Dolores Sanchez-Nino, Maria; Valino-Rivas, Lara; Cuarental, Leticia; Ribagorda, Marta; Pintor-Chocano, Aranzazu; Favero, Chiara; Alvarez-Llamas, Gloria; Cleary Catalina, Martin; Fernandez-Fernandez, Beatriz; Vanessa Perez-Gomez, Maria; Alegre de Montaner, Emma Raquel; Fernandez Prado, Raul; Rojas Rivera, Jorge; Ramos Verde, Ana Maria; Carriazo, Sol; Luis-Lima, Sergio; Sanchez-Rodriguez, Jinny; Pizarro Sanchez, Soledad; Ruiz Ortega, Marta; Gonzalez Parra, Emilio; Rayego Mateos, Sandra; Cannata Ortiz, Pablo Javier; Marquez Exposito, Laura; Tejera-Munoz, Antonio; Marchant, Vanessa; Tejedor-Santamaria, Lucia; Alique Agilar, Matilde; Diekmann, Fritz; Bayes Genis, Beatriz; Oppenheimer Salinas, Federico; Ramirez Bajo, Maria Jose; Banon Maneus, Elisenda; Arias Guillen, Marta; Rovira Juarez, Jordi; Lazo Rodriguez, Marta; Revuelta Vicente, Ignacio; Blasco Pelicano, Josep Miquel; Quintana Porras, Luis Fernando; Abreu Aguiar, Pedro Ventura; Xipell Font, Marc; Molina Andujar, Alicia; Cucchiari, David; Montagud Marrah, Enrique; Campistol Plana, Josep M; Julio Pineiro, Gaston; Martinez Salgado, Carlos; Morales Martin, Ana, I; Lopez Hernandez, Francisco J; Eleno Balboa, Nelida; Prieto Vicente, Marta; Fuentes Calvo, Isabel; Ramudo Gonzalez, Laura; Vicente Vicente, Laura; Sancho Martinez, Sandra M; Casanova Paso, Alfredo G; Pescador Garriel, Moises; Vaquero Lopez, Juan Jose; Cuadro Palacios, Ana Maria; Sucunza Saenz, David; Garcia Garcia, Patricia; Acena Bonilla, Jose Luis; Fernandez Rodriguez, Manuel A; Domingo Galan, Alberto; Merino Marcos, Estibaliz; Carreras Perez-Aradros, Javier; Manzano San Jose, Ruben; Maqueda Zelaya, Francisco; Sans Panades, Ester; Atarejos Salido, Julia; Torra Balcells, Roser; Ars Criach, Elisabet; Diaz Encarnacion, Montserrat; Guirado Perich, Lluis; Canal Girol, Cristina; Arce Terroba, Yolanda; Pybus Oliveras, Marc; Ejarque Vila, Laia; Serra Cabanas, Nuria; Facundo Molas, Carme; Silva Torres, Irene; Lamas Pelaez, Santiago; Rey Serra, Carlos; Tituana Fajardo, Jessica Paola; Herrero Lahuerta, Jose Ignacio; Miguel Herranz, Veronica; Martin Malo, Alejandro; Munoz Castaneda, Juan Rafael; Rodriguez Ortiz, Maria Encarnacion; Martinez Moreno, Julio Manuel; Raya Bermudez, Ana Isabel; Moyano Peregrin, Cayetana; Aguilera Tejero, Escolastico; Lopez Villalba, Ignacio; Carmona Munoz, Andres; Pendon Ruiz De Mier, Maria Victoria; Pineda Martos, Carmen Maria; Lopez Baltanas, Rodrigo; Rodelo Haad, Cristian; Franquesa Bartolome, Marcella; Lauzurica Valdemoros, Ricardo; Borras Serres, Francisco Enrique; Navarro Diaz, Maruja; Juega Marino, Francisco Javier; Canas Sole, Laura; Troya Saborido, Maria Isabel; Soler Majoral, Jordi; Lopez Martinez, Marina; Ruiz San Millan, Juan Carlos; Lopez-Hoyos, Marcos; Benito-Hernandez, Adalberto; San Segundo, David; Valero, Rosalia; Coto Garcia, Eliecer; Gomez De Ona, Juan; Cuesta Llavona, Elias; Santos Rodriguez, Fernando; Lorca Gutierrez, Rebeca; Gil Pena, Helena; Lopez, Veronica; Sola, Eugenia; Cabello, Mercedes; Caballero, Abelardo; Leon, Myriam; Alonso, Juana; Navarro-Gonzalez, Juan; Donate-Correa, Javier; Martin-Nunez, Ernesto; Delgado, Nayra Perez; Gigarran-Guldris, Secundino; Gorriz Teruel, Jose Luis; Martinez Castelao, Alberto; Valdivielso Revilla, Jose Manuel; Martinez Martinez, Cristina; Bozic Stanojevic, Milica; Castro Boque, Eva; Sans Rosell, Maria Nuria; Maria De Lamo, Virtudes; Diaz Tocados, Juan Miguel; Garcia Carrasco, Alicia; Bermudez Lopez, Marcelino; Caus Enriquez, Maite; Osuna Ortega, Antonio; Wangensteen Fuentes, Rosemary; De Gracia Guindo, Maria del Carmen; Ruiz Fuentes, Maria del Carmen; O'Valle Ravassa, Francisco; Caba Molina, Mercedes; Ramirez Tortosa, Cesar Luis; Del Moral Garrido, Raimundo Garcia; Jacobs-Cacha, Conxita; Bestard Matamoros, Oriol; Moreso Mateos, Francesc; Emilia Meneghini, Maria Antonia; Sellares Roig, Joana; Torres Betsabe, Irina; Lopez Larrea, Carlos; Suarez Alvarez, Beatriz; Diaz Corte, Maria del Carmen; Rodrigues-Diez, Raul R; Lopez Vazquez, Antonio; Gonzalez Rodriguez, Segundo; Vidal Castineira, Jose Ramon; Martin Martin, Cristina; Martinez Borra, Jesus; Bajo Rubio, Maria Auxiliadora; Del Peso Gilsanz, Gloria; Lopez Cabrera, Manuel; Jimenez Heffernan, Jose Antonio; Ossorio Gonzalez, Marta; Costero Gonzalez, Olga; Gonzalez Garcia, Maria Elena; Sandoval Correa, Pilar; Afonso Ramos, Sara; Lopez Oliva, Maria; Rivas Becerra, Begona; Vega Cabrera, Cristina; Gonzalez Mateo, Guadalupe Tirma; Sanchez Villanueva, Rafael; Alvarez Garcia, Laura; Cannata Andia, Jorge B; Naves Diaz, Manuel; Fernandez Martin, Jose Luis; Carrillo Lopez, Natalia; Panizo Garcia, Sara; Alonso Montes, Cristina; Rodriguez Garcia, Minerva; Martinez Luengas, Inigo Lozano; Sanchez Alvarez, Emilio; Martinez Arias, Laura; Martin Carro, Beatriz; Martin Virgala, Julia; Garcia Gonzalez, Miguel; Lamas Barreiro, Jose Maria; Perez Fontan, Miguel; Otero Gonzalez, Alfonso; Cuina Barja, Luz Maria; Sanchez Barreiro, Alejandro; Pazos Arias, Beatriz; Hernandez, Angel Alonso; Pardo Perez, Maria; Calvino Varela, Jesus; Amigo Lechuga, Jorge; Diaz Rodriguez, Candido; Garcia Murias, Maria; Barcia de la Iglesia, Ana Maria; Bouza Pineiro, Pablo; Cordido Eijo, Adrian; Carrera Cachaza, Noa; Vizoso Gonzalez, Marta; Lloberas Blanch, Nuria; Sola Martinez, Ana Maria; Hueso Val, Miguel; Bordignon Draibe, Juliana; Melilli, Edoardo; Manonelles Montero, Anna; Montero Perez, Nuria; Fulladosa Oliveras, Xavier; Crespo Barrio, Marta; Pascual Santos, Julio; Barrios Barrera, Clara; Perez Saez, Maria Jose; Redondo Pachon, Maria Dolores; Arias Cabrales, Carlos; Buxeda Porras, Anna; Rodriguez Garcia, Eva; Palau Gonzalez, Vanesa; Llinas Mallol, Laura; Riera Oliva, Marta; Ruiz Torres, Maria Piedad; Lopez Ongil, Susana; Calleros Basilio, Laura; Olmos Centenera, Gemma; Ramirez Chamond, Manuel Rafael; Sequera Ortiz, Patricia; Garcia Fernandez, Nuria; Benito Boillos, Alberto; Varo Cenarruzabeitia, Nerea; Fernandez Seara, Maria Asuncion; Diaz Dorronsoro, Ines; Martin Moreno, Paloma; Javier Lavilla, Francisco; Torres, Armando; Marrero Miranda, Domingo; Rodriguez Hernandez, Aurelio Pastor; De Bonis Redondo, Eduardo; Porrini, Esteban; Cobo Caso, Maria de los Angeles; Perez Tamajon, Maria Lourdes; Rufino Hernandez, Margarita; Garcia Rebollo, Maria Sagrario; Delgado Mallen, Patricia; Alvarez Gonzalez, Alejandra; Gonzalez Rinne, Ana Maria; Miquel Rodriguez, Rosa; Estupinan Torres, Sara; Alvarez Sosa, Diego; Escamilla Cabrera, Beatriz; Zamora Rodriguez, Nayara; Farina Hernandez, Arminda; Rodriguez Gamboa, Maria Jose; Maria de los Angeles, Cobo Caso; Maria Lourdes, Perez Tamajon; Hernandez Margarita, Rufino; Maria Sagrario, Garcia Rebollo; Mallen Patricia, Delgado; Gonzalez Alejandra, Alvarez; Ana Maria, Gonzalez Rinne; Rodriguez Rosa, Miquel; Garcia Bermejo, Maria Laura; Fernandez Lucas, Milagros; Conde Moreno, Elisa; Salinas Munoz, Laura; Serrano Huertas, Silvia; Rodriguez Serrano, Esperanza Macarena; Ramos Munoz, Miren Edurne; Crespo Toro, Lorena; Blanco Agudo, Carolina Pilar; Portoles, Jose; Marques, Maria; Rubio, Esther; Sanchez-Sobrino, Beatriz; Garcia-Menendez, Estefanya; Lazaro Fernandez, Alberto; Rodriguez Benitez, Patrocinio; Gonzalez-Nicolas Gonzalez, Maria Angeles; Lopez Gallardo, Meritxell; Fernandez Juarez, Gema Maria; Gutierrez Martinez, Eduardo; Praga Terente, Manuel; Tato Ribera, Ana; Cavero Escribano, Teresa; Caravaca Fontan, Fernando; Shabaka Fernandez, Amir; Robles Perez-Monteoliva, Nicolas Roberto; Luna Huerta, Enrique; Gervasini Rodriguez, Guillermo; Hernandez, Sergio Barroso; Mota Zamorano, Sonia; Lopez Gomez, Juan Manuel; Gonzalez, Alvaro Gil

Affiliations

Abstract

The uptake of the current concept of chronic kidney disease (CKD) by the public, physicians and health authorities is low. Physicians still mix up CKD with chronic kidney insufficiency or failure. In a recent manuscript, only 23% of participants in a cohort of persons with CKD had been diagnosed by their physicians as having CKD while 29% has a diagnosis of cancer and 82% had a diagnosis of hypertension. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. A prevalent view is that for those in whom kidneys fail, the problem is "solved" by dialysis or kidney transplantation. However, the main burden of CKD is accelerated aging and all-cause and cardiovascular premature death. CKD is the most prevalent risk factor for lethal COVID-19 and the factor that most increases the risk of death in COVID-19, after old age. Moreover, men and women undergoing KRT still have an annual mortality which is 10-100-fold higher than similar age peers, and life expectancy is shortened by around 40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth global cause of death by 2040 and the second cause of death in Spain before the end of the century, a time when 1 in 4 Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded CIBER network research structure in Spain. Leading Spanish kidney researchers grouped in the kidney collaborative research network REDINREN have now applied for the RICORS call of collaborative research in Spain with the support of the Spanish Society of Nephrology, ALCER and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true. However, only the highest level of research funding through the CIBER will allow to adequately address the issue before it is too late. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.

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