SUCCOR cone study: conization before radical hysterectomy

March 9, 2022

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SUCCOR cone study: conization before radical hysterectomy

Publicated to: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 32 (2): 117-124 - 2022-01-01 32(2), DOI: 10.1136/ijgc-2021-002544

Authors:

Chacon E, Manzour N, Zanagnolo V, Querleu D, Núñez-Córdoba JM, Martin-Calvo N, Căpîlna ME, Fagotti A, Kucukmetin A, Mom C, Chakalova G, Shamistan A, Gil Moreno A, Malzoni M, Narducci F, Arencibia O, Raspagliesi F, Toptas T, Cibula D, Kaidarova D, Meydanli MM, Tavares M, Golub D, Perrone AM, Poka R, Tsolakidis D, Vujić G, Jedryka MA, Zusterzeel PLM, Beltman JJ, Goffin F, Haidopoulos D, Haller H, Jach R, Yezhova I, Berlev I, Bernardino M, Bharathan R, Lanner M, Maenpaa MM, Sukhin V, Feron JG, Fruscio R, Kukk K, Ponce J, Minguez JA, Vázquez-Vicente D, Castellanos T, Boria F, Alcazar JL, Chiva L, SUCCOR study group, SUCCOR study Group

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Affiliations

Amsterdam University Medical Centres, Amsterdam, Noord-Holland, Netherlands. - Author

Azienda Ospedaliero-Universitaria di Bologna Policlinico SantOrsola-Malpighi, Bologna, Italy. - Author

Clinica Universidad de Navarra Departamento de Ginecologia y Obstetricia, Pamplona, Navarra, Spain. - Author

Clinica Universidad de Navarra, Pamplona, Navarra, Spain. - Author

Clinical Hospital Center Rijeka, Rijeka, Croatia. - Author

Clinical Hospital Center, Zagreb, Croatia. - Author

Department of Gynecologic Oncology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. - Author

Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland. - Author

Department of Gynecology, Centre Oscar Lambret, Lille, France. - Author

Department of Obstetrics and Gynecology, University of Prague, Prague, Czech Republic. - Author

Department of Preventive Medicine and Public Health, Universidad de Navarra, Pamplona, Spain. - Author

Department of Surgery, LISOD-Israeli Oncological Hospital, Kyiv, Ukraine. - Author

Division of Gynecologic Oncology, 1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece. - Author

Emergency County Hospital Targu-Mures, Targu Mures, Romania. - Author

Endoscopica Malzoni, Center for Advanced Endoscopic Gynecologic Surgery, Center for Advanced Endoscopic Gynecologic Surgery, Avellino, Italy. - Author

General Hospital of Thessaloniki Papageorgiou, Thessaloniki, Central Macedonia, Greece. - Author

Gynaecology, LUMC, Leiden, Netherlands. - Author

Gynecologic Oncology, Saglik Bilimleri University Antalya Research and Training Hospital, Antalya, Turkey. - Author

Gynecologic Oncology, Universidad de Navarra, Pamplona, Navarra, Spain. - Author

Gynecological Oncology, Radboudumc, Nijmegen, Netherlands. - Author

Gynecology, Instituto Português de Oncologia de Lisboa, Lisboa, Lisboa, Portugal. - Author

Gynecology, Vall d'Hebron Hospital, Sant Cugat Del Vallés, Barcelona, Spain. - Author

IPO-PORTO, Porto, Porto, Portugal. - Author

Istituto Europeo di Oncologia, Milano, Anognnn, Italy. - Author

Kardinal Schwarzenberg'sches Krankenhaus, Schwarzach, Steiermark, Austria. - Author

Lviv Oncology Center, Lviv, Ukraine. - Author

National Center of Oncology, Baku, Azerbaijan. - Author

North-Western State Medical University, NN Petrov Research Institute of Oncology, Saint-Petersburg, Saint-Petersburg, Russian Federation. - Author

Obstetrics and Gynecology, Unit of Gynecologic Oncology, Institute of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. - Author

Obstetrics and Gynecology, University of Liege, Liege, Belgium. - Author

Oncogynecology, Kazahskij Naucno-issledovatel'skij Institut Onkologii i Radiologii, Almaty, Kazakhstan. - Author

Oncological Gynecology, Lower Silesian Cancer Center, Wroclaw, Poland. - Author

Queen Elizabeth Hospital, Gateshead, Gateshead, UK. - Author

Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia, Italy. - Author

Surgery, Institut Bergonie, Bordeaux, France. - Author

Universitat Autònoma de Barcelona, Barcelona, Barcelona, Spain. - Author

University Hospital Agostino Gemelli Gynaecological Oncology Complex Operative Unit, Roma, Lazio, Italy. - Author

University Hospitals of Leicester NHS Trust, Leicester, Leicester, UK. - Author

University Maternal Hospital Canary Islands, Las Palma, Spain. - Author

University Oncologic Hospital, Sofia, Bulgaria. - Author

Abstract

To evaluate disease-free survival of cervical conization prior to radical hysterectomy in patients with stage IB1 cervical cancer (International Federation of Gynecology and Obstetrics (FIGO) 2009).A multicenter retrospective observational cohort study was conducted including patients from the Surgery in Cervical Cancer Comparing Different Surgical Aproaches in Stage IB1 Cervical Cancer (SUCCOR) database with FIGO 2009 IB1 cervical carcinoma treated with radical hysterectomy between January 1, 2013, and December 31, 2014. We used propensity score matching to minimize the potential allocation biases arising from the retrospective design. Patients who underwent conization but were similar for other measured characteristics were matched 1:1 to patients from the non-cone group using a caliper width ≤0.2 standard deviations of the logit odds of the estimated propensity score.We obtained a weighted cohort of 374 patients (187 patients with prior conization and 187 non-conization patients). We found a 65% reduction in the risk of relapse for patients who had cervical conization prior to radical hysterectomy (hazard ratio (HR) 0.35, 95% confidence interval (CI) 0.16 to 0.75, p=0.007) and a 75% reduction in the risk of death for the same sample (HR 0.25, 95% CI 0.07 to 0.90, p=0.033). In addition, patients who underwent minimally invasive surgery without prior conization had a 5.63 times higher chance of relapse compared with those who had an open approach and previous conization (HR 5.63, 95% CI 1.64 to 19.3, p=0.006). Patients who underwent minimally invasive surgery with prior conization and those who underwent open surgery without prior conization showed no differences in relapse rates compared with those who underwent open surgery with prior cone biopsy (reference) (HR 1.94, 95% CI 0.49 to 7.76, p=0.349 and HR 2.94, 95% CI 0.80 to 10.86, p=0.106 respectively).In this retrospective study, patients undergoing cervical conization before radical hysterectomy had a significantly lower risk of relapse and death.© IGCS and ESGO 2022. No commercial re-use. See rights and permissions. Published by BMJ.

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Keywords

Cervical cancerHysterectomyLaparoscopesLaparotomySurgery

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 13/85, thus managing to position itself as a Q1 (Primer Cuartil), in the category Obstetrics & Gynecology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 5.57. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-05, the following number of citations:

WoS: 32
Europe PMC: 14

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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Austria; Azerbaijan; Belgium; Bulgaria; Croatia; Czech Republic; France; Greece; Hungary; Israel; Italy; Kazakhstan; Netherlands; Oman; Poland; Portugal; Russia; Turkey; Ukraine; United Kingdom.

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SUCCOR cone study: conization before radical hysterectomy

Affiliations

Abstract

Keywords

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Leadership analysis of institutional authors

Indexed in

Citations

Altmetrics

Analysis of institutional authors

Share

SUCCOR cone study: conization before radical hysterectomy

Affiliations

Abstract

Keywords

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Impact and social visibility

Leadership analysis of institutional authors