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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Cuervas-Mons, VAuthor

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January 24, 2022
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Decreased Long-Term Severe Acute Respiratory Syndrome Coronavirus 2-Specific Humoral Immunity in Liver Transplantation Recipients 12 Months After Coronavirus Disease 2019

Publicated to:LIVER TRANSPLANTATION. 28 (6): 1039-1050 - 2022-06-01 28(6), DOI: 10.1002/lt.26389

Authors: Caballero-Marcos, Aranzazu; Jesus Citores, Maria; Alonso-Fernandez, Roberto; Rodriguez-Peralvarez, Manuel; Valerio, Maricela; Graus Morales, Javier; Cuervas-Mons, Valentin; Cachero, Alba; Loinaz-Segurola, Carmelo; Inarrairaegui, Mercedes; Castells, Lluis; Pascual, Sonia; Vinaixa-Aunes, Carmen; Gonzalez-Grande, Rocio; Otero, Alejandra; Tome, Santiago; Tejedor-Tejada, Javier; Fernandez-Yunquera, Ainhoa; Gonzalez-Dieguez, Luisa; Nogueras-Lopez, Flor; Blanco-Fernandez, Gerardo; Diaz-Fontenla, Fernando; Javier Bustamante, Francisco; Romero-Cristobal, Mario; Martin-Mateos, Rosa; Arias-Milla, Ana; Calatayud, Laura; Marcacuzco-Quinto, Alberto A; Fernandez-Alonso, Victor; Gomez-Gavara, Concepcion; Munoz, Patricia; Banares, Rafael; Antonio Pons, Jose; Salcedo, Magdalena

Affiliations

Clin Univ Navarra, Liver Unit, Pamplona, Spain - Author
Complejo Hosp Univ Badajoz, Dept HPB Surg & Liver Transplantat, Badajoz, Spain - Author
Cruces Univ Hosp, Liver Transplant & Hepatol Unit, Baracaldo, Spain - Author
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain - Author
Hosp A Coruna, Liver Transplant Unit, La Coruna, Spain - Author
Hosp Gen Univ Alicante, Liver Unit, Alicante, Spain - Author
Hosp Gen Univ Gregorio Maranon, Dept Clin Microbiol & Infect Dis, Madrid, Spain - Author
Hosp Ramon & Cajal, Dept Digest Dis, IRYCIS, Madrid, Spain - Author
Hosp Reg Univ Malaga, Dept Liver Transplantat, Malaga, Spain - Author
Hosp Univ & Politecn La Fe, Dept Hepatol & Liver Transplantat, Valencia, Spain - Author
Hosp Univ 12 Octubre, Dept Hepatol HPB Surg Transplantat, Madrid, Spain - Author
Hosp Univ Bellvitge, Dept Clin Microbiol & Infect Dis, IDIBELL, Barcelona, Spain - Author
Hosp Univ Bellvitge, Liver Transplant Unit, IDIBELL, Barcelona, Spain - Author
Hosp Univ Cent Asturias, Div Gastroenterol & Hepatol, Oviedo, Spain - Author
Hosp Univ Cent Asturias, Liver Unit, Oviedo, Spain - Author
Hosp Univ Reina Sofia, Dept Hepatol & Liver Transplantat, IMIBIC, Cordoba, Spain - Author
Hosp Univ Rio Hortega, Dept Gastroenterol, Hepatol & Liver Transplantat Unit, Valladolid, Spain - Author
Hosp Univ Santiago, Dept Liver Transplantat, Santiago De Compostela, Spain - Author
Hosp Univ Virgen de la Arrixaca, Dept Surg, Liver Transplantat Unit, IMIB,Liver Unit, Murcia, Spain - Author
Hosp Virgen de las Nieves, Dept Hepatol & Liver Transplantat, Granada, Spain - Author
Inst Invest Puerta Hierro Segovia Aran IDIPHISA, Madrid, Spain - Author
Inst Invest Sanitaria Puerta de Hierro Segovia Ar, Dept Internal Med, Madrid, Spain - Author
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Internal Med, Liver Unit, Barcelona, Spain - Author
Univ Autonoma Madrid, Hosp Puerta de Hierro, Hepatol & Liver Transplant Unit, IDIPHIMSA, Madrid, Spain - Author
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med, Hepatol & Liver Transplantat Unit, Madrid, Spain - Author
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Abstract

Long-term humoral immunity and its protective role in liver transplantation (LT) patients have not been elucidated. We performed a prospective multicenter study to assess the persistence of immunoglobulin G (IgG) antibodies in LT recipients 12 months after coronavirus disease 2019 (COVID-19). A total of 65 LT recipients were matched with 65 nontransplanted patients by a propensity score including variables with recognized impact on COVID-19. LT recipients showed a lower prevalence of anti-nucleocapsid (27.7% versus 49.2%; P = 0.02) and anti-spike IgG antibodies (88.2% versus 100.0%; P = 0.02) at 12 months. Lower index values of anti-nucleocapsid IgG antibodies were also observed in transplantation patients 1 year after COVID-19 (median, 0.49 [interquartile range, 0.15-1.40] versus 1.36 [interquartile range, 0.53-2.91]; P < 0.001). Vaccinated LT recipients showed higher antibody levels compared with unvaccinated patients (P < 0.001); antibody levels reached after vaccination were comparable to those observed in nontransplanted individuals (P = 0.70). In LT patients, a longer interval since transplantation (odds ratio, 1.10; 95% confidence interval, 1.01-1.20) was independently associated with persistence of anti-nucleocapsid IgG antibodies 1 year after infection. In conclusion, compared with nontransplanted patients, LT recipients show a lower long-term persistence of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. However, SARS-CoV-2 vaccination after COVID-19 in LT patients achieves a significant increase in antibody levels, comparable to that of nontransplanted patients.

Keywords

BiotecnologíaCiências biológicas iEngenharias iiiGastroenterology & hepatologyGeneral medicineHepatologyMedicina iMedicina iiMedicina iiiSaúde coletivaSurgeryTransplantation

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal LIVER TRANSPLANTATION due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position 20/213, thus managing to position itself as a Q1 (Primer Cuartil), in the category Surgery. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.32. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.14 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 5.59 (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-06, the following number of citations:

  • WoS: 6
  • Scopus: 8
  • Open Alex: 10

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 63.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 69 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 17.85.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).
  • The number of mentions in news outlets: 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 84% according to the mBERT algorithm developed by Aurora University.