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This research was funded by the Ministry of Science, Innovation and Universities of Spain (MICINN) and the European Regional Development Fund FEDER, grant number RTI2018-095166-B-I00. supported through, as well as Comunidad de Madrid (B-2017/BMD-3751 NOVELREN-CM and Ref. S2017/BMD3684 MOIR-2) and Instituto de Salud Carlos III, European FEDER (grant number FIS-PI19/00166) and CIBEROBN. LMM is recipient of MCINN FPU grant (FPU19/05505).

Analysis of institutional authors

Martos-Moreno, GaAuthorGraell, MAuthorArgente, JCorresponding Author

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Article

Unveiling Metabolic Phenotype Alterations in Anorexia Nervosa through Metabolomics

Publicated to:Nutrients. 13 (12): 4249- - 2021-12-01 13(12), DOI: 10.3390/nu13124249

Authors: Mayo-Martinez, Laura; Ruperez, Francisco J.; Martos-Moreno, Gabriel A.; Graell, Montserrat; Barbas, Coral; Argente, Jesus; Garcia, Antonia;

Affiliations

CSIC, Madrid 28049, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERS, Madrid 28029, Spain - Author
La Princesa Res Inst, Madrid 28006, Spain - Author
UAM, IMDEA Food Inst, CEI, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Dept Pediat, Madrid 28006, Spain - Author
Univ Nino Jesus, Hosp Infantil, Dept Pediat Endocrinol, Madrid 28009, Spain - Author
Univ Nino Jesus, Hosp Infantil, Dept Pediat, Madrid 28009, Spain - Author
Univ Nino Jesus, Hosp Infantil, Dept Psychiat, Madrid 28009, Spain - Author
Univ San Pablo CEU, Fac Pharm, Ctr Metabol & Bioanal CEMBIO, Monteprincipe Campus, Madrid 28660, Spain - Author
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Abstract

Anorexia nervosa (AN) is a mental disorder characterized by an intense fear of weight gain that affects mainly young women. It courses with a negative body image leading to altered eating behaviors that have devastating physical, metabolic, and psychological consequences for the patients. Although its origin is postulated to be multifactorial, the etiology of AN remains unknown, and this increases the likelihood of chronification and relapsing. Thus, expanding the available knowledge on the pathophysiology of AN is of enormous interest. Metabolomics is proposed as a powerful tool for the elucidation of disease mechanisms and to provide new insights into the diagnosis, treatment, and prognosis of AN. A review of the literature related to studies of AN patients by employing metabolomic strategies to characterize the main alterations associated with the metabolic phenotype of AN during the last 10 years is described. The most common metabolic alterations are derived from chronic starvation, including amino acid, lipid, and carbohydrate disturbances. Nonetheless, recent findings have shifted the attention to gut-microbiota metabolites as possible factors contributing to AN development, progression, and maintenance. We have identified the areas of ongoing research in AN and propose further perspectives to improve our knowledge and understanding of this disease.

Keywords

anorexiamass spectrometrymetabolic phenotypemetabolismmetabolomicsAdolescentsAnorexiaD-amino acidsDisordersEndocrineFatty-acidsMass spectrometryMechanismsMetabolic phenotypeMetabolismMetabolomicsMicrobiotaMortalityProfilesSodium-butyrate

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 15/90, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-18:

  • Scopus: 5
  • OpenCitations: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 94.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 93 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.5.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

the author responsible for correspondence tasks has been ARGENTE OLIVER, JESUS.