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This work was supported by grants from Fundacio La Marato de TV3 (201822-10), Agencia Estatal de Investigacion-FEDER (PID2019-110609RB-C21-C22/AEI/10.13039/501100011033), Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias FIS-FEDER(PI13/00598, PI16/00617, PI20/00090), and RedinRen-FEDER(RD16/0009/0013).

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Vilches, CAuthor

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December 28, 2021
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Long-Term Evolution of the Adaptive NKG2C(+) NK Cell Response to Cytomegalovirus Infection in Kidney Transplantation: An Insight on the Diversity of Host-Pathogen Interaction

Publicated to:JOURNAL OF IMMUNOLOGY. 207 (7): 1882-1890 - 2021-10-01 207(7), DOI: 10.4049/jimmunol.2100055

Authors: Ataya, Michelle; Redondo-Pachon, Dolores; Llinas-Mallol, Laura; Yelamos, Jose; Alari-Pahissa, Elisenda; Perez-Saez, Maria J.; Altadill, Mireia; Raich-Regue, Dalia; Vilches, Carlos; Pascual, Julio; Crespo, Marta; Lopez-Botet, Miguel;

Affiliations

Hosp Mar, Dept Nephrol, Barcelona, Spain - Author
Hosp Mar, Dept Pathol, Immunol Lab, Barcelona, Spain - Author
Inst Hosp Mar Invest Med, Barcelona, Spain - Author
Inst Invest Sanitaria Puerta Hierro Segovia Arana, Immunogenet HLA, Madrid, Spain - Author
Univ Pompeu Fabra, Doctor Aiguader 88, Barcelona 08003, Spain - Author
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Abstract

Human CMV infection is frequent in kidney transplant recipients (KTR). Pretransplant Ag-specific T cells and adaptive NKG2C(+) NK cells associate with reduced incidence of infection in CMV+ KTR. Expansions of adaptive NKG2C+ NK cells were reported in posttransplant CMV-infected KTR. To further explore this issue, NKG2C(+) NK, CD8+, and TcR gamma delta T cells were analyzed pretransplant and at different time points posttransplant for >= 24 mo in a cohort of CMV+ KTR (n = 112), stratified according to CMV viremia detection. In cryopreserved samples from a subgroup (n = 49), adaptive NKG2C+ NK cell markers and T cell subsets were compared after a longer follow-up (median, 56 mo), assessing the frequencies of CMV-specific T cells and viremia at the last time point. Increased proportions of NKG2C+ NK, CD8+, and TcR gamma delta T cells were detected along posttransplant evolution in viremia(+) KTR. However, the individual magnitude and kinetics of the NKG2C(+) NK response was variable and only exceptionally detected among viremia(-) KTR, presumably reflecting subclinical viral replication events. NKG2C+ expansions were independent of KLRC2 zygosity and associated with higher viral loads at diagnosis; no relation with other clinical parameters was perceived. Increased proportions of adaptive NKG2C(+) NK cells (CD57(+), ILT2(+), FceRIy-) were observed after resolution of viremia long-term posttransplant, coinciding with increased CD8(+) and V delta 2(-) y delta T cells; at that stage CMV-specific T cells were comparable to viremia(-) cases. These data suggest that adaptive NKG2C(+) NK cells participate with T cells to restore CMV replication control, although their relative contribution cannot be discerned. The Journal of Immunology, 2021, 207: 1882-1890.

Keywords

Cd94/nkg2c receptorDiseaseExpansionFcr-gammaHeterogeneityNatural-killer-cellProtectionReactivationRecipientsSubset

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF IMMUNOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology and Allergy.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.76, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-21, the following number of citations:

  • WoS: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 17.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 15 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).