{rfName}
Gu

Indexed in

License and use

Icono OpenAccess

Altmetrics

Analysis of institutional authors

Chaparro MAuthorGisbert JpAuthor

Share

October 4, 2021
Publications
>
Review

Gut microbiota and dietary factors as modulators of the mucus layer in inflammatory bowel disease

Publicated to:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 22 (19): 10224- - 2021-10-01 22(19), DOI: 10.3390/ijms221910224

Authors: Fernandez-Tome, Samuel; Ortega Moreno, Lorena; Chaparro, Maria; Gisbert, Javier P

Affiliations

Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas - Author
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28006, Spain - Author
Hospital Universitario de la Princesa - Author
Univ Autonoma Madrid UAM, Hosp Univ La Princesa, Inst Invest Sanitaria Princesa IIS IP, Gastroenterol Unit, Madrid 28006, Spain - Author
See more

Abstract

The gastrointestinal tract is optimized to efficiently absorb nutrients and provide a com-petent barrier against a variety of lumen environmental compounds. Different regulatory mechanisms jointly collaborate to maintain intestinal homeostasis, but alterations in these mechanisms lead to a dysfunctional gastrointestinal barrier and are associated to several inflammatory conditions usually found in chronic pathologies such as inflammatory bowel disease (IBD). The gastrointestinal mucus, mostly composed of mucin glycoproteins, covers the epithelium and plays an essential role in digestive and barrier functions. However, its regulation is very dynamic and is still poorly understood. This review presents some aspects concerning the role of mucus in gut health and its alterations in IBD. In addition, the impact of gut microbiota and dietary compounds as environmental factors modulating the mucus layer is addressed. To date, studies have evidenced the impact of the three-way interplay between the microbiome, diet and the mucus layer on the gut barrier, host immune system and IBD. This review emphasizes the need to address current limita-tions on this topic, especially regarding the design of robust human trials and highlights the potential interest of improving our understanding of the regulation of the intestinal mucus barrier in IBD.

Keywords

dietary compoundsgastrointestinal barriergut microbiotainflammatory bowel diseaseAnimalsDietDietary compoundsGastrointestinal barrierGastrointestinal microbiomeGut microbiotaHumansInflammatory bowel diseaseInflammatory bowel diseasesIntestinal mucosaMucusMucus layerNutrients

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/297, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.24. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.73 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 5.13 (source consulted: Dimensions Oct 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-10-16, the following number of citations:

  • WoS: 14
  • Scopus: 33
  • Europe PMC: 7

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 49.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 48 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.75.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/716791

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Fernández-Tomé S) and Last Author (PEREZ GISBERT, FRANCISCO JAVIER).

the author responsible for correspondence tasks has been Fernández-Tomé S.