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Analysis of institutional authors

Diez, Juan JAuthorAlvarez Escola, CristinaAuthorLecumberri Santamaria, BeatrizAuthor

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Recovery of parathyroid function in patients with thyroid cancer treated by total thyroidectomy: An analysis of 685 patients with hypoparathyroidism at discharge of surgery

Publicated to:Endocrinologia Diabetes y Nutricion. 68 (6): 398-407 - 2021-01-01 68(6), DOI: 10.1016/j.endien.2021.10.009

Authors: Díez Gómez, Juan José; Anda Apiñániz, Enma; Sastre Marcos, Julia; Pérez Corral, Begoña; Álvarez Escolá, Cristina; Manjón, Laura; Paja Fano, Miguel; Sambo Salas, Marcel; Santiago Fernández, Piedad; Blanco Carrera, Concepción; Galofré Ferrater, Juan Carlos; Navarro González, Elena; Zafón Llopis, Carles; Sanz, Eva; Oleaga Alday, Amelia; Bandrés Nivela, Orosia; Donnay Candil, Sergio; Megía Colet, Ana; Picallo, María; Sanchez Ragnarson, Cecilia; Baena Nieto, Gloria; Fernández García, José Carlos; Lecumberri Santamaría, Beatriz; Sahun de la Vega, Manuel; Romero Lluch, Ana; Iglesias Lozano, Pedro

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Abstract

We aimed to study the predictive factors for recovery of parathyroid function in hypoparathyroid patients after total thyroidectomy for thyroid cancer.We designed a retrospective, multicentre and nation-wide analysis of patients with total thyroidectomy who were seen in twenty endocrinology departments from January to March 2018. We selected patients with histologically proven thyroid cancer and retrieved information related to surgical procedure and thyroid cancer features. Survival analysis and Cox regression analysis were used to study the relationship between these variables and the recovery of parathyroid function.From 685 patients with hypoparathyroidism at discharge of surgery, 495 (72.3%) recovered parathyroid function over time. Kaplan-Meier analysis showed that this recovery was significantly related to the presence of specialized surgical team (P<0.001), identification of parathyroid glands at surgery (P<0.001), papillary histopathology (P=0.040), and higher levels of postoperative calcium (Ca) (P<0.001) and parathyroid hormone (PTH) (P<0.001). Subjects with gross extrathyroidal extension (P=0.040), lymph node metastases (P=0.004), and surgical re-intervention after initial surgery (P=0.024) exhibited a significant risk of persistence of hypoparathyroidism. Multivariate Cox regression analysis showed that the significant and independent factors for recovery of parathyroid function were postoperative concentrations of Ca (P=0.038) and PTH (P=0.049). The presence of lymph node metastases was a negative predictor of recuperation of parathyroid function (P=0.042) in this analysis.In patients with thyroid cancer, recovery of parathyroid function after total thyroidectomy was directly related to postoperative Ca and PTH concentrations, and inversely related to lymph node metastases.Copyright © 2020 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.

Keywords

Cancer de tiroidesHipoparatiroidismo permanentePermanent hypoparathyroidismRecoveryRecuperaciónThyroid cancerThyroidectomyTiroidectomía

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Endocrinologia Diabetes y Nutricion, and although the journal is classified in the quartile Q4 (Agencia WoS (JCR)), its regional focus and specialization in Endocrinology & Metabolism, give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-06-08:

  • Europe PMC: 1
  • OpenCitations: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.25.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (DIEZ GOMEZ, JUAN JOSE) .