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This study was performed based on a collaboration between Enzo Emanuele and Biodue S.p.A. with partial sponsorship and supply of test materials. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Pareja-Galeano, HAuthor
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Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne

Publicated to:Beneficial Microbes. 7 (5): 625-630 - 2016-01-01 7(5), DOI: 10.3920/BM2016.0089

Authors: Fabbrocini, G; Fabbrocini, G; Bertona, M; Bertona, M; Picazo, O; Picazo, O; Pareja-Galeano, H; Pareja-Galeano, H; Monfrecola, G; Monfrecola, G; Emanuele, E; Emanuele, E

Affiliations

‎ 2E Sci, Via Monte Grappa 13, I-27038 Robbio, PV, Italy - Author
‎ Nutrisci Educ & Consulting, Ave Forcas Armadas, P-1600082 Lisbon, Portugal - Author
‎ Univ Europea & Res Inst I 12, Tajo S-N,Villaviciosa Odon, Madrid 28670, Spain - Author
‎ Univ Naples Federico II, Dept Clin Med & Surg, Dermatol Sect, Via S Pansini 5, I-80131 Naples, Italy - Author

Abstract

Systemic supplementation with probiotics is increasingly being explored as a potential treatment strategy for skin disorders. Because both the gut-skin axis and dysregulation of insulin signalling have been implicated in the pathogenesis of adult acne, we designed the current study to evaluate the effect of supplementation with the probiotic strain Lactobacillus rhamnosus SP1 (LSP1) on skin expression of genes involved in insulin signalling and acne improvement in adult subjects. A pilot, randomised, double-blinded, placebo-controlled study was conducted with 20 adult subjects (14 females and 6 males; mean age: 33.7 +/- 3.3 years) with acne. Over a 12-week period, the probiotic group (n=10) consumed a liquid supplement containing LSP1 at a dose of 3x10(9) cfu/day (75 mg/day), whereas the placebo group (n=10) received a liquid lacking probiotics. Paired skin biopsies - one obtained before treatment initiation and one obtained at the end of the 12-week treatment period - were analysed for insulin-like growth factor 1 (IGF1) and forkhead box protein O1 (FOXO1) gene expression. The clinical criterion for efficacy was the investigator's global improvement rating on a five-point scale. Compared with baseline, the probiotic group showed a 32% (P<0.001) reduction, as well as a 65% increase (P<0.001) in IGF1 and FOXO1 gene expression in the skin, respectively. No such differences were observed in the placebo group. Patients in the probiotic group had an adjusted odds ratio of 28.4 (95% confidence interval = 2.2-411.1, P<0.05) to be rated by physicians as improved/markedly improved (versus worsened or unchanged) compared with the placebo group. We conclude that supplementation with the probiotic strain LSP1 normalises skin expression of genes involved in insulin signalling and improves the appearance of adult acne.

Keywords
acnegene expressioninsulin signallinglactobacillus rhamnosus sp1probioticskinAcneDietGene expressionGgGrowth-factor-iHigh-fatInsulin signallingIntestinal permeabilityLactobacillus rhamnosus sp1PathogenesisProbioticProbioticsPropionibacterium-acnesResistanceSkinSupplementationVulgaris

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Beneficial Microbes due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2016, it was in position 32/81, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Nutrition & Dietetics. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Microbiology (Medical).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.82. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.9 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 9.66 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-02, the following number of citations:

  • WoS: 82
  • Scopus: 97
  • OpenCitations: 88
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 207.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 207 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 70.072.
  • The number of mentions on the social network Facebook: 8 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Italy; Portugal.