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This research was funded by National Heart, Lung, and Blood Institute grant number HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, UL1-TR-001881, DK063491, N02-HL-64278, R01HL98077, N02-HL-64278, HL071205, UL1TR001881, DK063491, RD831697, P50 ES015915, R01HL071051, R01HL071205, R01HL071250, R01HL071251, R01HL071258, and R01HL071259; National Center for Research Resources grant number UL1RR033176; National Center for Advancing Translational Sciences grant number UL1TR001881, United States Environmental Protection Agency grant number RD831697; and National Institute of Environmental Health Sciences grant number P42ES010349 and 5T32ES007141.

Analysis of institutional authors

Tellez-Plaza, MariaAuthor

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June 15, 2021
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Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Publicated to:International Journal of Environmental Research and Public Health. 15 (6): - 2018-06-05 15(6), DOI: 10.3390/ijerph15061179

Authors: Balakrishnan, Poojitha; Jones, Miranda R.; Vaidya, Dhananjay; Tellez-Plaza, Maria; Post, Wendy S.; Kaufman, Joel D.; Bielinski, Suzette J.; Taylor, Kent; Francesconi, Kevin; Goessler, Walter; Navas-Acien, Ana;

Affiliations

‎ Columbia Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA - Author
‎ Fdn Invest Hosp Clin Valencia INCLIVA, Valencia 46010, Spain - Author
‎ Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Los Angeles, CA 90502 USA - Author
‎ Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA - Author
‎ Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA - Author
‎ Johns Hopkins Sch Med, Dept Med, Baltimore, MD 21205 USA - Author
‎ Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria - Author
‎ Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA - Author
‎ Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA - Author
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Abstract

We investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Urinary arsenic species, including inorganic arsenic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (Ab), were measured using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) and corrected for organic sources from seafood consumption by regressing Ab on arsenic species using a validated method. Principal components of arsenic metabolism were also used as independent phenotypes. We conducted linear regression of arsenic traits with allelic dosage of candidate single nucleotide polymorphisms (SNPs) rs12768205 (G > A), rs3740394 (A > G), and rs3740393 (G > C) measured using Illumina MetaboChip. Models were stratified by non-Hispanic white vs. all other race/ethnicity and adjusted for age, sex, arsenic exposure, study site, and population stratification. Consistent with previous studies, rs12768205 showed evidence for strongest association (non-Hispanic white: iAs% -0.14 (P 0.83), MMA% -0.66 (0.49), DMA% 0.81(0.49); other race/ethnicity: 0.13 (0.71), -1.21 (0.09), 1.08 (0.20)). No association, however, passed the strict Bonferroni p-value. This was a novel study among an ethnically diverse population exposed to low arsenic levels.

Keywords

arsenicas3mtepidemiologygenetic susceptibilitygeographymesaArsenicAs3mtCardiovascular-diseaseDrinking-waterEpidemiologyGenetic susceptibilityGenome-wide associationGeographyMesaMethylationRiskSeafood intakeToxicityUrineUs populationValidationWhole-blood

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal of Environmental Research and Public Health due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2018, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Health, Toxicology and Mutagenesis.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.1. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 2.79 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-13, the following number of citations:

  • WoS: 9
  • Scopus: 10

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-13:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 47 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Austria; Timor-Leste; United States of America.