{rfName}
An

Indexed in

License and use

Icono OpenAccess

Citations

14

Altmetrics

Grant support

This study was supported by a grant from the Fondo de Investigaciones Sanitarias (PI19/01282) to MF. The authors thank David Munoz and technical staff of the Animal Facility at the Facultad de Medicina for the care of animals.

Analysis of institutional authors

Ferrer, MCorresponding Author

Share

May 17, 2021
Publications
>
Article
Sí

Androgen Deprivation Therapy in Patients With Prostate Cancer Increases Serum Levels of Thromboxane A(2): Cardiovascular Implications

Publicated to:Front Cardiovasc Med. 8 (653126): 653126- - 2021-01-01 8(653126), DOI: 10.3389/fcvm.2021.653126

Authors: Alvarez-Maestro, Mario; Eguibar, Aritz; Chanca, Patricia; Klett-Mingo, Mercedes; Gomez Rivas, Juan; Buno-Soto, Antonio; de Bethencourt, Fermin R.; Ferrer, Mercedes;

Affiliations

‎ Hosp Clin San Carlos, Dept Urol, Madrid, Spain - Author
‎ Hosp Univ La Paz, Serv Anal Clin, Madrid, Spain - Author
‎ Hosp Univ La Paz, Serv Urol, Madrid, Spain - Author
‎ IdiPAZ, Grp Invest Neonatol, Madrid, Spain - Author
‎ IdiPAZ, Grp Invest Urol, Madrid, Spain - Author
‎ UAM, Fac Med, Dept Fisiol, Madrid, Spain - Author
See more

Abstract

Introduction: Androgens have been described as important players in the regulation of vascular function/structure through their action on the release and effect of vasoactive factors, such as prostanoids. Patients with prostate cancer (PCa) under androgen deprivation therapies (ADTs) present increased risk of cardiovascular mortality. Since thromboxane A(2) (TXA(2)) is one of the most studied prostanoids and its involvement in different cardiovascular diseases has been described, the aim of this study was to investigate: (i) the effect of ADT on the serum levels of TXA(2) in PCa patients and its possible link to the redox status and (ii) the effect of the non-hydrolyzable TXA(2) analog U-46619 on the function of the aorta of male rats. Methods: The levels of TXA(2) and total antioxidant status in 50 healthy subjects, 54 PCa patients, and 57 PCa under ADT were evaluated. These determinations were accompanied by levels of testosterone and C-reactive protein as an inflammation marker. In aortic segments from male rats, the U46619-induced effects on: (i) the vasomotor responses to acetylcholine (ACh), to the NO donor sodium nitroprusside (SNP), to the carbon monoxide-releasing molecule-3 (CORM-3), and to noradrenaline (NA) and (ii) the expression of cyclooxygenase-2 (COX-2), heme oxygenase-1 (HO-1), and phosphorylated ERK1/2 were analyzed. Results: The serum level of TXA(2) in patients with PCa was increased with respect to healthy subjects, which was further increased by ADT. There was no modification in the total antioxidant status among the three experimental groups. In aortic segments from male rats, the TXA(2) analog decreased the endothelium-dependent relaxation and the sensitivity of smooth muscle cells to NO, while it increased the vasoconstriction induced by NA; the expression of COX-2, HO-1, and pERK1/2 was also increased. Conclusions: ADT increased, along with other inflammatory/oxidative markers, the serum levels of TXA(2). The fact that TXA(2) negatively impacts the vascular function of the aorta of healthy male rats suggests that inhibition of TXA(2)-mediated events could be considered a potential strategy to protect the cardiovascular system.

Keywords

androgen deprivation therapy (adt)endotheliumprostate cancerthromboxane a2 (txa2)Androgen deprivation therapy (adt)EndotheliumProstate cancerThromboxane a(2) (txa(2))Vascular function

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Front Cardiovasc Med due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Cardiology and Cardiovascular Medicine.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.76, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-16, the following number of citations:

  • WoS: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-16:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 13.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.55.
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/715933

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (FERRER PARRA, MERCEDES).

the author responsible for correspondence tasks has been FERRER PARRA, MERCEDES.