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Bailén MAuthor

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May 5, 2021
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Sesquiterpene lactones from artemisia absinthium. Biotransformation and rearrangement of the insect antifeedant 3α-hydroxypelenolide

Publicated to:Plants-Basel. 10 (5): 891- - 2021-01-01 10(5), DOI: 10.3390/plants10050891

Authors: Fraga BM; Díaz CE; Bailén M; González-Coloma A

Affiliations

CSIC - Instituto de Ciencias Agrarias (ICA) - Author
CSIC - Instituto de Productos Naturales y Agrobiologia (IPNA) - Author
Inst Ciencias Agr, CSIC, Serrano 115 Dpdo, Madrid 28006, Spain - Author
Inst Prod Nat & Agrobiol, CSIC, Avda Astrofis Sanchez 3, San Cristobal la Laguna 38206, Spain - Author
Univ Autonoma Madrid, Fac Med, Dept Med Prevent & Salud Publ & Microbiol, C Arzobispo Morcillo S-N, Madrid 28049, Spain - Author
Universidad Autónoma de Madrid - Author
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Abstract

Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of Artemisia absinthium. In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus Mucor plumbeus affording the corresponding 1β, 10α-epoxide. A cadinane derivative was formed by an acid rearrangement produced in the culture medium, but not by the enzymatic system of the fungus. Furthermore, 3α-hydroxypelenolide showed strong antifeedant effects against Leptinotarsa decemlineata and cytotoxic activity to Sf9 insect cells, while the biotransformed compounds showed antifeedant postingestive effects against Spodoptera littoralis.

Keywords

3?-hydroxypelenolide3α-hydroxypelenolideabsilactoneajenjolartemisia absinthiumasteraceaebiological activitybiotransformationmucor plumbeus3 alpha-hydroxypelenolide3α-hydroxypelenolideAbsilactoneAjenjolArtemisia absinthiumAsteraceaeBiological activityBiotransformationConfigurationConstituentsDiterpenesFlavonoidsHansonlactoneLiquid-chromatographyMicrobiological transformationMucorMucor plumbeusOccurring terpene derivativesPopulationsTriterpenes

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plants-Basel due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 39/239, thus managing to position itself as a Q1 (Primer Cuartil), in the category Plant Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.06, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-08, the following number of citations:

  • WoS: 1
  • Scopus: 3
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-08:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 17.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 18 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 0.25.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/697622