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Grant support

This research was funded by Cantabria Labs and by the Spanish grant from Instituto de Saud Carlos III, MINECO and FEDER funds (PI18/00708). M.G. and P.D.-W are supported from the Spanish Ministry (MINECO) and from Comunidad Autonoma de Madrid (CAM), respectively. The APC was funded by Cantabria Labs.

Analysis of institutional authors

Lorrio, SAuthor

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Article

The Aqueous Extract of Polypodium leucotomos (Fernblock(R)) Regulates Opsin 3 and Prevents Photooxidation of Melanin Precursors on Skin Cells Exposed to Blue Light Emitted from Digital Devices

Publicated to:Antioxidants. 10 (3): 1-16 - 2021-03-01 10(3), DOI: 10.3390/antiox10030400

Authors: Portillo, Mikel; Mataix, Manuel; Alonso-Juarranz, Miguel; Lorrio, Silvia; Villalba, Maria; Rodriguez-Luna, Azahara; Gonzalez, Salvador;

Affiliations

‎ Alcala de Henares Univ, Dept Med & Med Specialties, Madrid 28805, Spain - Author
‎ Autonoma Univ Madrid UAM, Inst Ramon y Cajal Invest Sanit IRYCIS, Fac Sci, Dept Biol, Madrid 28049, Spain - Author
‎ Cantabria Labs, Innovat & Dev, Madrid 28043, Spain - Author
‎ Cantabria Labs, Med Affairs Dept, Madrid 28043, Spain - Author
‎ San Carlos Clin Hosp, Maxillofacial Surg Unit, Madrid 28040, Spain - Author
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Abstract

The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the induction of oxidative stress and long-lasting pigmentation. The protective effect of an aqueous extract of Polypodium leucotomos (Fernblock(R)) is known. Our aim was to investigate the action mechanism of Fernblock(R) against pigmentation induced by blue light from digital devices. Human fibroblasts (HDF) and murine melanocytes (B16-F10) were exposed to artificial blue light (a 400-500 nm LED lamp). Cell viability, mitochondrial morphology, and the expression of the mitogen-activated protein kinase (MAPK) p38, known markers involved in the melanogenesis pathway, were evaluated. The activation of Opsin-3, a membrane protein sensitive to blue light that triggers the activation of the enzyme tyrosinase responsible for melanogenesis in melanocytes, was also analyzed. Our results demonstrated that pretreatment with Fernblock(R) prevents cell death, alteration of mitochondrial morphology, and phosphorylation of p38 in HDF exposed to blue light. In addition, Fernblock(R) significantly reduced the activation of Opsin-3 in melanocytes and the photo-oxidation of melanin, preventing its photodegradation. In sum, Fernblock(R) exerts beneficial effects against the detrimental impact of blue light from digital devices and could prevent early photoaging, while maintaining skin homeostasis.

Keywords

blue lighthyperpigmentationmelanogenesisopsin-3polypodium leucotomosBlue lightHyperpigmen-tationHyperpigmentationMelanogenesisOpsin-3PhotoxidationPolypodium leucotomos

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 4/63, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.33. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.57 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 4.77 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-16, the following number of citations:

  • WoS: 15
  • Scopus: 29
  • OpenCitations: 21

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-16:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 42 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/704350

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Portillo, M) .