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Grant support

This work was supported by FONDECYT grant 1170425 from Agencia Nacional de Investigacion y Desarrollo de Chile (ANID), and fellowships OAICE-CAB-03-031-2015 from Universidad de Costa Rica and PED-118-2015-I from Ministerio de Ciencia, Tecnologia y Telecomunicaciones de Costa Rica.

Analysis of institutional authors

Sanchez-Ferrer, CfAuthorPeiro, CAuthor

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Article

Resolvin D1 and E1 promote resolution of inflammation in rat cardiac fibroblast in vitro

Publicated to:MOLECULAR BIOLOGY REPORTS. 48 (1): 57-66 - 2021-01-01 48(1), DOI: 10.1007/s11033-020-06133-8

Authors: Salas-Hernandez, Aimee; Espinoza-Perez, Claudio; Vivar, Raul; Espitia-Corredor, Jenaro; Lillo, Jose; Parra-Flores, Pablo; Sanchez-Ferrer, Carlos F.; Peiro, Concepcion; Diaz-Araya, Guillermo;

Affiliations

‎ Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Madrid, Spain - Author
‎ Univ Autonoma Madrid, Dept Pharmacol, Fac Med, Madrid, Spain - Author
‎ Univ Chile, Adv Ctr Chron Dis ACCDiS, Fac Chem & Pharmaceut Sci, Santos Dumont 964, Santiago, Chile - Author
‎ Univ Chile, Dept Chem Pharmacol & Toxicol, Fac Chem & Pharmaceut Sci, Santos Dumont 964, Santiago, Chile - Author
‎ Univ Chile, Fac Med, Santos Dumont 964, Santiago, Chile - Author
‎ Univ Chile, Pharmacol Program, Inst Biomed Sci, Independencia 1027, Santiago, Chile - Author
‎ Univ Costa Rica, Fac Pharm, Dept Pharmacol Toxicol & Pharmacodependence, San Jose, Costa Rica - Author
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Abstract

Cardiac fibroblasts (CFs) have a key role in the inflammatory response after cardiac injury and are necessary for wound healing. Resolvins are potent agonists that control the duration and magnitude of inflammation. They decrease mediators of pro-inflammatory expression, reduce neutrophil migration to inflammation sites, promote the removal of microbes and apoptotic cells, and reduce exudate. However, whether resolvins can prevent pro-inflammatory-dependent effects in CFs is unknown. Thus, the present work was addressed to study whether resolvin D1 and E1 (RvD1 and RvE1) can prevent pro-inflammatory effects on CFs after lipopolysaccharide (LPS) challenge. For this, CFs were stimulated with LPS, in the presence or absence of RvD1 or RvE1, to analyze its effects on intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), monocyte adhesion and the cytokine levels of tumor necrosis factor alpha (TNF-alpha), interleukin-6(IL-6), interleukin-1beta (IL-1 beta), monocyte chemoattractant protein-1 (MCP-1) and interleukin-10 (IL-10). Our results showed that CFs are expressing ALX/FPR2 and ChemR23, RvD1 and RvE1 receptors, respectively. RvD1 and RvE1 prevent the increase of ICAM-1 and VCAM-1 protein levels and the adhesion of spleen mononuclear cells to CFs induced by LPS. Finally, RvD1, but not RvE1, prevents the LPS-induced increase of IL-6, MCP-1, TNF-alpha, and IL-10. In conclusion, our findings provide evidence that in CFs, RvD1 and RvE1 might actively participate in the prevention of inflammatory response triggered by LPS.

Keywords

cardiac fibroblastscytokinesresolvin d1Cardiac fibroblastsCytokinesResolvin d1Resolvin e1

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MOLECULAR BIOLOGY REPORTS due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned en el Cuartil Q4 for the agency WoS (JCR) in the category Biochemistry & Molecular Biology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.33. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 1.67 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 3.07 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-22, the following number of citations:

  • WoS: 15
  • Scopus: 18
  • OpenCitations: 18

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-22:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 25.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 25 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Chile; Costa Rica.