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Analysis of institutional authors

González-Amor MAuthorBriones AmAuthorMiguel MAuthor

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October 19, 2020
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Characterization of novel synthetic polyphenols: Validation of antioxidant and vasculoprotective activities

Publicated to: Antioxidants. 9 (9): 1-23 - 2020-01-01 9(9), DOI: 10.3390/antiox9090787

Authors:

de Vega MJP; Moreno-Fernández S; Pontes-Quero GM; González-Amor M; Vázquez-Lasa B; Sabater-Muñoz B; Briones AM; Aguilar MR; Miguel M; González-Muñiz R
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Affiliations

Alodia Farmaceut SL, Santiago Grisolia 2 D130-L145, Madrid 28760, Spain - Author
Alodia Farmacéutica SL - Author
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV) - Author
CIBER BBN, Networking Biomed Res Ctr Bioengn Biomat & Nanome, Madrid 28029, Spain - Author
CIBER Bioingenieria, Biomateriales y Nanomedicina - Author
CSIC - Instituto de Ciencia y Tecnologia de Polimeros (ICTP) - Author
CSIC - Instituto de Quimíca Médica (IQM) - Author
CSIC UAM, Inst Invest Ciencias Alimentac, CEI UAM, C Nicolas Cabrera 9, Madrid 28049, Spain - Author
CSIC UPV, Inst Biol Mol & Celular Plantas IBMCP, Valencia 46022, Spain - Author
CSIC, Inst Ciencia & Tecnol Polimeros, Juan de la Cierva 3, Madrid 28006, Spain - Author
CSIC, Inst Quim Med, Juan De La Cierva 3, Madrid 28006, Spain - Author
CSIC-UAM - Instituto de Investigacion en Ciencias de la Alimentacion (CIAL) - Author
CSIC-UPV - Instituto de Biologia Molecular y Celular de Plantas Primo Yufera (IBMCP) - Author
Ctr Invest Biomed Red Enfermedades Cardiovasc, Madrid 28029, Spain - Author
Univ Autonoma Madrid, Inst Invest, Fac Med, Dept Farmacol,Biomed Hosp La Paz, Arzobispo Morcillo 4, Madrid 28029, Spain - Author
Universidad Autónoma de Madrid - Author
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Abstract

© 2020 by the authors. Antioxidant compounds, including polyphenols, have therapeutic effects because of their anti-inflammatory, antihypertensive, antithrombotic and antiproliferative properties. They play important roles in protecting the cardiovascular and neurological systems, by having preventive or protective effects against free radicals produced by either normal or pathological metabolism in such systems. For instance, resveratrol, a well-known potent antioxidant, has a counteracting effect on the excess of reactive oxygen species (ROS) and has a number of therapeutic benefits, like anti-inflammatory, anti-cancer and cardioprotective activities. Based on previous work from our group, and on the most frequent OH substitutions of natural polyphenols, we designed two series of synthetically accessible bis-polyhydroxyphenyl derivatives, separated by amide or urea linkers. These compounds exhibit high antioxidant ability (oxygen radical absorbance capacity (ORAC) assay) and interesting radical scavenging activity (RSA) values (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and α,α-diphenyl-β-picrylhydrazyl (DPPH) tests). Some of the best polyphenols were evaluated in two biological systems, endothelial cells (in vitro) and whole aorta (ex vivo), highly susceptible for the deleterious effects of prooxidants under different inflammatory conditions, showing protection against oxidative stress induced by inflammatory stimuli relevant in cardiovascular diseases, i.e., Angiotensin II and IL-1β. Selected compounds also showed strong in vivo antioxidant properties when evaluated in the model organism Saccharomyces cerevisiae.
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Keywords

abtsantioxidantsdpphnadph oxidaseoracpolyhydroxyphenyl amidespolyhydroxyphenyl ureassaccharomyces cerevisiaeAbtsAntioxidantsDpphNadph oxidaseOracOxidative stressPolyhydroxyphenyl amidesPolyhydroxyphenyl ureasProteinsResponsesSaccharomyces cerevisiaeSaccharomyces-cerevisiaeVasculoprotection

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 11/143, thus managing to position itself as a Q1 (Primer Cuartil), in the category Food Science & Technology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-06:

  • WoS: 8
  • Scopus: 8
  • Europe PMC: 4
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 38.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 38 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.
  • The number of mentions on the social network X (formerly Twitter): 15 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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