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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Pintado-Berninches L.Corresponding AuthorPintado-Berninches, LauraCorresponding Author

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October 19, 2020
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GSE4, a small dyskerin- and GSE24.2-related peptide, induces telomerase activity, cell proliferation and reduces DNA damage, oxidative stress and cell senescence in dyskerin mutant cells

Publicated to:PLoS ONE. 10 (11): e0142980-e0142980 - 2015-11-01 10(11), DOI: 10.1371/journal.pone.0142980

Authors: Iarriccio L; Manguán-García C; Pintado-Berninches L; Mancheño J; Molina A; Perona R; Sastre L

Affiliations

Adv Med Projects, Madrid, Spain - Author
Advanced Projects Division - Author
CIBER de Enfermedades Raras - Author
CIBER Enfermedades Raras, Valencia, Spain - Author
CSIC - Instituto de Química Física Rocasolano (IQFR) - Author
CSIC, Inst Quim Fis Rocasolano, Madrid, Spain - Author
CSIC-UAM - Instituto de Investigaciones Biomédicas Alberto Sols (IIBM) - Author
Hosp Univ La Paz, IdiPaz, Biomarkers & Expt Therapeut Canc, Madrid, Spain - Author
Hospital Universitario La Paz - Author
IdiPAZ, Madrid, Spain - Author
Instituto de Investigacion Hospital Universitario La Paz (IdiPAZ) - Author
UAM, CSIC, Inst Invest Biomed, Madrid, Spain - Author
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Abstract

© 2015 Iarriccioet al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Dyskeratosis congenita is an inherited disease caused by mutations in genes coding for telomeric components. It was previously reported that expression of a dyskerin-derived peptide, GSE24.2, increases telomerase activity, regulates gene expression and decreases DNA damage and oxidative stress in dyskeratosis congenita patient cells. The biological activity of short peptides derived from GSE24.2 was tested and one of them, GSE4, that probed to be active, was further characterized in this article. Expression of this eleven amino acids long peptide increased telomerase activity and reduced DNA damage, oxidative stress and cell senescence in dyskerin-mutated cells. GSE4 expression also activated c-myc and TERT promoters and increase of c-myc, TERT and TERC expression. The level of biological activity of GSE4 was similar to that obtained by GSE24.2 expression. Incorporation of a dyskerin nuclear localization signal to GSE24.2 did not change its activity on promoter regulation and DNA damage protection. However, incorporation of a signal that increases the rate of nucleolar localization impaired GSE24.2 activity. Incorporation of the dyskerin nuclear localization signal to GSE4 did not alter its biological activity. Mutation of the Aspartic Acid residue that is conserved in the pseudouridine synthase domain present in GSE4 did not impair its activity, except for the repression of c-myc promoter activity and the decrease of c-myc, TERT and TERC gene expression in dyskerin-mutated cells. These results indicated that GSE4 could be of great therapeutic interest for treatment of dyskeratosis congenita patients.

Keywords

Administração pública e de empresas, ciências contábeis e turismoAdministração, ciências contábeis e turismoAgricultural and biological sciences (miscellaneous)AnthropologyAntropologia / arqueologiaArchaeologyArquitetura, urbanismo e designAstronomia / físicaBiochemistry, genetics and molecular biology (miscellaneous)BiodiversidadeBiologyBiotecnologíaCiência da computaçãoCiência de alimentosCiência política e relações internacionaisCiências agrárias iCiências ambientaisCiências biológicas iCiências biológicas iiCiências biológicas iiiCiências sociais aplicadas iComunicação e informaçãoDemographyDireitoEconomiaEducaçãoEducação físicaEnfermagemEngenharias iEngenharias iiEngenharias iiiEngenharias ivEnsinoEnvironmental studiesFarmaciaGeneral agricultural and biological sciencesGeneral biochemistry,genetics and molecular biologyGeneral medicineGeociênciasGeografíaHistoriaHistory & philosophy of scienceHuman geography and urban studiesInterdisciplinarInterdisciplinary research in the social sciencesLetras / linguísticaLinguística e literaturaMatemática / probabilidade e estatísticaMateriaisMedicina iMedicina iiMedicina iiiMedicina veterinariaMedicine (miscellaneous)MultidisciplinaryMultidisciplinary sciencesNutriçãoOdontologíaPlanejamento urbano e regional / demografiaPsicologíaPsychologyQuímicaSaúde coletivaServiço socialSociologíaSociologyZootecnia / recursos pesqueiros

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PLoS ONE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position 11/62, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.57, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 14
  • Scopus: 13

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 35.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 36 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.5.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 55% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Iarriccio L) and Last Author (Sastre L).

the authors responsible for correspondence tasks have been Iarriccio L, Manguan-Garcia C, PINTADO BERNINCHES, LAURA, SASTRE GARZON, LEANDRO, Perona R and Sastre L.