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October 19, 2020
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Analysis of biochemical parameters in major burn patients: New prognostic factors. from the basic to the clinical research

Publicated to:Cirugia Plastica Ibero-Latinoamericana. 38 (4): 305-312 - 2012-10-01 38(4), DOI: 10.4321/S0376-78922012000400001

Authors: Maldonado A; Küntscher M; Sillero A

Affiliations

Catedrático de la Heidelberg Universität - Author
Facultad de Medicina. Bioquímica. Universidad Autónoma de Madrid - Author
Facultad de Medicina. Universidad Autónoma de Madrid - Author
Hospital Universitario de Getafe - Author
Universidad Autónoma de Madrid - Author
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Abstract

Our objective is the calculation of the plasma electrical charge in major burn patients, by means of a computer programme focussed on predicting patient mortality. The PICAL computer software (own development) starts off with the objective of calculating the plasmatic charge and the influence of ions and proteins applied to 143 patients in the Major Burn Patient Unit in the Unfallkrankenhaus Hospital in Berlin (Germany). A statistical study is carried out to define patient mortality once the previous calculations have been performed, considering: 1) their biochemical parameters in the first 48 hours, 2) their clinical factors: age, total burned surface area, depth of the burn, presence of inhalation syndrome, etc. A logistic regression analysis was made using these data calculating the mortality predictive function, which was validated by a group of 35 new patients. The importance of each plasmatic ion and proteins was calculated in the electrical balance of the patients with major burns. Age, burned surface area, pH and [Mg2+] were introduced for the study of mortality in these patients via statistical analysis. From the study it was confirmed that anions [HCO3-] and [Cl-], together with cation [Na+] are the ions with most influence on the plasmatic balance of major burn patients. Protein concentration has a lower incidence on this balance: a loss of 50% in albumin concentration during the first 48 hours is equivalent to a loss of 1 mmol/l in the [HCO3-] concentration. It can also be stated that the use of parameters pH and [Mg2+] can improve mortality prediction in these patients.

Keywords

Burn patientsMortality prediction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Cirugia Plastica Ibero-Latinoamericana, Q3 Agency Scopus (SJR), its regional focus and specialization in Surgery, give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-02:

  • Scopus: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 9 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Germany.

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Sillero A).