{rfName}
Cy

Indexed in

License and use

Citations

55

Altmetrics

Analysis of institutional authors

Oliva Aldamiz, HoracioAuthorDel Pozo VAuthorPalomino PAuthorLahoz CAuthor

Share

October 19, 2020
Publications
>
Article
No

Cytokine mRNA expression in lung tissue from toxic oil syndrome patients: A TH2 immunological mechanism

Publicated to:TOXICOLOGY. 118 (1): 61-70 - 1997-03-14 118(1), DOI: 10.1016/S0300-483X(96)03584-6

Authors: Del Pozo V; De Andrés B; Gallardo S; Cárdaba B; De Arruda-Chaves E; Cortegano M; Jurado A; Palomino P; Oliva H; Aguilera B; Posada M; Lahoz C

Affiliations

REUNI - Author
Universidad Autónoma de Madrid - Author

Abstract

In 1981, an epidemic occurred in Spain, toxic oil syndrome (TOS), in people who consumed rapeseed oil denatured with 2% aniline, and it was one of the largest intoxication epidemics ever recorded. In 1989, a similar disease, eosinophilia-myalgia syndrome (EMS) was reported in the USA and was associated with the ingestion of L-tryptophan. The pathologic findings in TOS showed primary endothelial injury, with cell proliferation and perivascular inflammatory infiltrates. Immunologic mechanisms have presumably been operative in the pathogenesis and perpetuation of TOS. Our previous findings pointed to a T-cell activation during acute phase of the disease. In order to analyze which T-cell subset is involved on TOS, we have developed an mRNA extraction procedure from paraffin-embedded lung tissues in patients with pulmonary involvement. We analyzed mRNA expression from different cytokines (IL-1, IL-2, IL-4, IL-5, IFN-γ, GM-CSF) and CD25 (interleukin 2 receptor) and CD23 (low affinity IgE receptor), using RT-PCR technique. In lung tissues from these patients a T-cell activation was observed. We found a significant increase in Th1 (P = 0.006) and Th2 (P = 0.003) cytokine profile in TOS patients with respect to controls. The increment in TH2 response with respect to TH1 is significant (P = 0.03) in TOS lung specimens. Non-significant differences were obtained in other cytokines and receptors studied as IL-1, CD25, CD23 and GM-CSF. Data presented in this paper are the first clear evidence that an immunological mechanism is directly implicated in this illness.

Keywords

CytokinesLung tissuesTh2-mechanismToxic oil syndrome

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal TOXICOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 1997, it was in position 20/63, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Toxicology. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría .

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-04:

  • WoS: 26
  • Scopus: 29

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (DEL POZO ABEJON, MARIA VICTORIA) and Last Author (LAHOZ NAVARRO, CARLOS).