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Fariña Sabaris, Maria Del CarmenAuthorRequena Caballero, LuisAuthorGomez Octavio, JuanAuthorSarasa JAuthorPacho EAuthor
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Follicular spicules of the nose: A peculiar cutaneous manifestation of multiple myeloma with cryoglobulinemia

Publicated to:JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 32 (5 PART 2): 834-839 - 1995-01-01 32(5 PART 2), DOI: 10.1016/0190-9622(95)91542-7

Authors: Requena L; Sarasa J; Masllorens F; Martín L; Piqué E; Olivares M; Fariña M; Prieto E; Pacho E; Octavio J

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Hospital Universitario Fundacion Jimenez Diaz - Author

Abstract

We describe a patient with multiple myeloma and cryoglobulinemia who had spicules with a horny appearance in the follicular openings of the face, particularly on the nose. Histopathologic study demonstrated that these spicules consisted of eosinophilic homogeneous deposits in the intercellular spaces between keratinocytes in the upper layers of the follicular infundibulum. Direct immunofluorescence, ultrastructural, and biochemical investigations revealed that these eosinophilic deposits were cryoprecipitates composed of IgG-k with electrophoretic characteristics identical to those of the paraprotein present in the serum of the patient. Hence we believe that these lesions are best referred to as pseudohyperkeratotic spicules of the nose, and that they are a characteristic cutaneous manifestation of patients with multiple myeloma and cryoglobulinemia. © 1995.

Keywords
Ciência de alimentosCiências biológicas iCiências biológicas iiCiências biológicas iiiDermatologyDermatology & venereal diseasesGeneral medicineInterdisciplinarMedicina iMedicina iiMedicina iiiOdontologíaSaúde coletiva

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-18:

  • WoS: 28
  • Scopus: 42
  • OpenCitations: 41
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-18:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Requena L) .