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Analysis of institutional authors

Correas Hornero, Maria IsabelAuthorMiguez DgAuthor

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June 27, 2020
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Midbody Remnant Inheritance Is Regulated by the ESCRT Subunit CHMP4C

Publicated to:iScience. 23 (6): 101244- - 2020-06-26 23(6), DOI: 10.1016/j.isci.2020.101244

Authors: Casares-Arias, Javier; Gonzalez, Maria Ujue; Paulo, Alvaro San; Ventimiglia, Leandro N; Sadler, Jessica B A; Miguez, David G; Labat-de-Hoz, Leticia; Rubio-Ramos, Armando; Rangel, Laura; Bernabe-Rubio, Miguel; Fernandez-Barrera, Jaime; Correas, Isabel; Martin-Serrano, Juan; Alonso, Miguel A

Affiliations

Consejo Superior de Investigaciones Científicas - Author
CSIC, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain - Author
CSIC, Inst Micro & Nanotecnol, Madrid 28760, Spain - Author
King's College London - Author
Kings Coll London, Fac Life Sci & Med, Dept Infect Dis, London SE1 9RT, England - Author
Univ Autonoma Madrid, Dept Condensed Matter Phys, Madrid 28049, Spain - Author
Univ Autonoma Madrid, Dept Mol Biol, Madrid 28049, Spain - Author
Universidad Autónoma de Madrid - Author
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Abstract

© 2020 The Authors The inheritance of the midbody remnant (MBR) breaks the symmetry of the two daughter cells, with functional consequences for lumen and primary cilium formation by polarized epithelial cells, and also for development and differentiation. However, despite its importance, neither the relationship between the plasma membrane and the inherited MBR nor the mechanism of MBR inheritance is well known. Here, the analysis by correlative light and ultra-high-resolution scanning electron microscopy reveals a membranous stalk that physically connects the MBR to the apical membrane of epithelial cells. The stalk, which derives from the uncleaved side of the midbody, concentrates the ESCRT machinery. The ESCRT CHMP4C subunit enables MBR inheritance, and its depletion dramatically reduces the percentage of ciliated cells. We demonstrate (1) that MBRs are physically connected to the plasma membrane, (2) how CHMP4C helps maintain the integrity of the connection, and (3) the functional importance of the connection.

Keywords

cell biologyimmunologyCell biologyCiliogenesisCytokinetic abscissionImmunologyIntegrityMachineryMechanismsNeurosciencePolarityPrimary cilia

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal iScience due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position 14/73, thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary Sciences.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-07:

  • WoS: 5
  • Scopus: 5
  • Europe PMC: 4

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-07:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 26 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.75.
  • The number of mentions on the social network X (formerly Twitter): 5 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United Kingdom.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Casares-Arias J) and Last Author (Alonso MA).