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Martinez, JoseAuthor

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August 5, 2019
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Fisiopatología del aneurisma de aorta abdominal: biomarcadores y nuevas dianas terapéuticas

Publicated to:Clinica e Investigacion en Arteriosclerosis. 31 (4): 166-177 - 2019-07-01 31(4), DOI: 10.1016/j.arteri.2018.10.002

Authors: Torres-Fonseca, Monica; Galan, Maria; Martinez-Lopez, Diego; Canes, Laia; Roldan-Montero, Raquel; Alonso, Judit; Reyero-Postigo, Teresa; Orriols, Mar; Mendez-Barbero, Nerea; Sirvent, Marc; Miguel Blanco-Colio, Luis; Martinez, Jose; Luis Martin-Ventura, Jose; Rodriguez, Cristina;Soc Espanola Arteriosclerosis

Affiliations

;UAM, Inst Invest Sanitaria, Hosp Univ Fdn Jimenez Diaz IIS FJD, Vasc Res Lab, Madrid, Spain      Autonomous University of Madrid;CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain      CIBER - Centro de Investigacion Biomedica en Red    CIBERCV;Hosp Santa Creu & Sant Pau, Inst Recerca, IIB St Pau, Barcelona, Spain      Autonomous University of Barcelona    Catalan Health Institute    Hospital Universitari Vall d'Hebron    Vall d'Hebron Institut de Recerca (VHIR)    Hospital of Santa Creu i Sant Pau;IIB St Pau, IIBB, CSIC, Barcelona, Spain      Consejo Superior de Investigaciones Cientificas (CSIC)    CSIC - Instituto de Investigaciones Biomedicas de Barcelona (IIBB);Hosp Badalona Germans Trias & Pujol, Barcelona, Spain      Hospital Germans Trias i Pujol - Author
CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain.      CIBER - Centro de Investigacion Biomedica en Red    CIBERCV - Author
Hosp Santa Creu & Sant Pau, Inst Recerca, IIB St Pau, Barcelona, Spain.      Autonomous University of Barcelona    Catalan Health Institute    Hospital Universitari Vall d'Hebron    Vall d'Hebron Institut de Recerca (VHIR)    Hospital of Santa Creu i Sant Pau - Author
UAM, Inst Invest Sanitaria, Hosp Univ Fdn Jimenez Diaz IIS FJD, Vasc Res Lab, Madrid, Spain.      Autonomous University of Madrid - Author
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Abstract

Abdominal aortic aneurysm (AAA) is a vascular pathology with a high rate of morbidity and mortality and a prevalence that, in men over 65 years, can reach around 8%. In this disease, usually asymptomatic, there is a progressive dilatation of the vascular wall that can lead to its rupture, a fatal phenomenon in more than 80% of cases. The treatment of patients with asymptomatic aneurysms is limited to periodic monitoring with imaging tests, control of cardiovascular risk factors and treatment with statins and antiplatelet therapy. There is no effective pharmacological treatment capable of limiting AAA progression or avoiding their rupture. At present, the aortic diameter is the only marker of risk of rupture and determines the need for surgical repair when it reaches values greater than 5.5cm. This review addresses the main aspects related to epidemiology, risk factors, diagnosis and clinical management of AAA, exposes the difficulties to have good biomarkers of this pathology and describes the strategies for the identification of new therapeutic targets and biomarkers in AAA. (C) 2018 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.

Keywords

abdominal aortic aneurysmaneurisma de aorta abdominalbiomarcadorbiomarkerfactores de riesgomanejo terapéuticorisk factorsAbdominal aortic aneurysmBiomarkerChlamydia-pneumoniaeCirculating biomarkersControlled trialConverting enzyme-inhibitorsDouble-blindDoxycyclineGrowth-rateMesenchymal stem-cellsRisk factorsRisk-factorsSmokingTherapeutic management

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinica e Investigacion en Arteriosclerosis, Q3 Agency Scopus (SJR), its regional focus and specialization in Pharmacology (Medical), give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 2.64, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 15.55 (source consulted: Dimensions Oct 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-10-26, the following number of citations:

  • WoS: 27
  • Scopus: 46

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-10-26:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 175 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.