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Garcia Berrocal, Jose RamonAuthorRamirez Camacho, RafaelAuthor

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February 3, 2014
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Ginkgo biloba extract (EGb761) protects against aging-related caspase-mediated apoptosis in rat cochlea

Publicated to: ACTA OTO-LARYNGOLOGICA. 130 (10): 1101-1112 - 2010-10-01 130(10), DOI: 10.3109/00016481003713657

Authors:

Nevado, Julian; Sanz, Ricardo; Sanchez-Rodriguez, Carolina; Ramon Garcia-Berrocal, Jose; Martin-Sanz, Eduardo; Angel Gonzalez-Garcia, Jose; Esteban-Sanchez, Jonathan; Ramirez-Camacho, Rafael
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Affiliations

CIBERER, Madrid, Spain - Author
Hosp Univ Getafe, Serv Otorrinolaringol, Getafe 28905, Madrid, Spain - Author
Hosp Univ Getafe, Unidad Invest, Getafe 28905, Madrid, Spain - Author
Hosp Univ La Paz, INGEMM, Madrid, Spain - Author
Hosp Univ Puerta Hierro Majadahonda, Serv Otorrinolaringol, Majadahonda, Madrid, Spain - Author
Hospital Universitario La Paz - Author
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Abstract

EGb761 treatment has a significant benefit with an early and preventive effect, reversing the deleterious effect of aging in the integrity of the rat cochlea, even in the late stage of the rat lifespan.We previously reported a significant relationship between aging and apoptosis in the rat cochlea. This study was designed to investigate the effects of Ginkgo biloba leaf extract (EGb761) on age-associated cochlear caspase activation.Sprague-Dawley rats (n = 80) divided into two groups according to their age (4 months old, younger, YR, and 12 months old, aged-mature, AM) were treated with 100 mg/kg/day body weight of EGb761 extract dissolved in tap water for two periods: 4 and 12 months. Then cochleae were harvested to measure caspase activities, ATP levels, total superoxide dismutase (SOD) activity, and caspase-3 gene expression. Auditory steady-state responses (ASSR) threshold shifts were also measured before sacrifice of the rats.EGb761 treatment prevents significantly aging-related caspase-induced activities within the cochleae in YR and AM rats. In the short EGb761 treatment, YR rats showed lower levels of caspase-3/7 than AM rats. In contrast, longer treatment did not show significant differences between YR and AM rats. Reduced caspase-3/7 activity in presence of EGb761 correlates with significant improvements of ASSR threshold shifts.
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Keywords

ActivationAuditory steady-state responseCaspase-3ConstituentsInhibitionOxidative stressPresbycusisPreventionSurvival

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal ACTA OTO-LARYNGOLOGICA due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2010, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous).

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-02:

  • WoS: 31
  • Scopus: 36
  • Europe PMC: 12
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-02:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 30 (PlumX).
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: OSLO.

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