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Analysis of institutional authors

Sanchez Perez, Maria IsabelAuthor or co-author of article in journal with external admissions assessment committeePintado Berninches, LauraAuthor or co-author of article in journal with external admissions assessment committee

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May 17, 2019
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Article

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

Publicated to:eLife. 8 (e39159): e39159- - 2019-04-02 8(e39159), DOI: 10.7554/eLife.39159

Authors: Celaya, Adelaide M; Celaya, Adelaide M; Sanchez-Perez, Isabel; Bermudez-Munoz, Jose M; Bermudez-Munoz, Jose M; Rodriguez-de la Rosa, Lourdes; Pintado-Berninches, Laura; Perona, Rosario; Murillo-Cuesta, Silvia; Varela-Nieto, Isabel

Affiliations

Autonomous Univ Madrid CSIC UAM, Inst Biomed Res Alberto Sols IIBM, Spanish Natl Res Council, Madrid, Spain - Author
Autonomous Univ Madrid, Fac Med, Biochem Dept, Madrid, Spain - Author
Consejo Superior de Investigaciones Científicas - Author
Ctr Biomed Network Res Rare Dis CIBERER, ISCIII, CIBER, Madrid, Spain - Author
Hosp La Paz, Inst Hlth Res IdiPAZ, Madrid, Spain - Author
Instituto de Investigacion Hospital Universitario La Paz (IdiPAZ) - Author
Instituto de Salud Carlos III - Author
UCLM CSIC, Biomed Unit, Madrid, Spain - Author
Universidad Autónoma de Madrid - Author
Universidad Autonoma de Madrid, Facultad de Medicina - Author
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Abstract

© 2019, Celaya et al. Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. Stress kinases are well-described elements of the response to otic injury and the otoprotective potential of JNK inhibitors is being tested in clinical trials. By contrast, there are no studies exploring the role of DUSP1 in hearing and hearing loss. Here we show that Dusp1 expression is age-regulated in the mouse cochlea. Dusp1 gene knock-out caused premature progressive hearing loss, as confirmed by auditory evoked responses in Dusp1-/- mice. Hearing loss correlated with cell death in hair cells, degeneration of spiral neurons and increased macrophage infiltration. Dusp1-/- mouse cochleae showed imbalanced redox status and dysregulated expression of cytokines. These data suggest that DUSP1 is essential for cochlear homeostasis in the response to stress during ageing.

Keywords

apoptosiscochleadual phosphataseshuman biologyinflammationmedicinemouseneuroscienceoxidative stressAcoustic stimulationAnimalsApoptosisCochleaCytokinesDisease models, animalDual phosphatasesDual specificity phosphatase 1Dusp1 protein, mouseEvoked potentials, auditoryGene expression profilingGene expression regulation, developmentalHair cells, auditoryHearing lossHuman biologyInflammationMedicineMice, inbred c57blMice, knockoutMouseNeuroscienceOxidation-reductionOxidative stressSensorineural hearing loss

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal eLife due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position 5/93, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.22. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 9.03 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 20
  • Scopus: 20
  • Europe PMC: 12

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 41.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 45 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.95.
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: https://repositorio.uam.es/handle/10486/689031

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Celaya, Adelaida M.) and Last Author (Varela Nieto, Isabel).