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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Fernandez Acenero, Maria JesusAuthorFernández Aceñero, M.j.AuthorMayoralas Alises, SagrarioAuthor

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October 21, 2017
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Factor de necrosis tumoral como marcador de inflamación precoz en fumadores sanos

Publicated to:MEDICINA CLINICA. 139 (2): 47-53 - 2012-01-01 139(2), DOI: 10.1016/j.medcli.2011.11.032

Authors: Díez Piña, Juan M; Fernández Aceñero, MJ; Llorente Alonso, María Jesús; Díaz Lobato, Salvador; Mayoralas Alises, Sagrario; Pérez Rodríguez, Esteban; Álvaro Álvarez, Dolores; Flórez Horcajada, Asunción; Pérez Rojo, Raquel

Affiliations

Hospital Universitario de Móstoles - Author
Hospital Universitario Fundacion Jimenez Diaz - Author
Hospital Universitario Ramón y Cajal - Author

Abstract

Smoking creates an inflammation that leads to lose of lung function. Tumor necrosis factor alpha (TNF-?) is a cytokine that plays an important role in the pathogenesis of chronic obstructive pulmonary disease. There is a need to develop methods for an early detection of an impaired lung function in smokers. We aimed to show that smokers have higher levels of TNF-? in serum and exhaled breath condensate (EBC). We also analysed the influence of sex, age and weight on TNF-?, and determined the association between smoking, pulmonary function and TNF-?.Prospective study of smokers and non-smokers without any known disease. Respiratory function tests, EBC and blood samples were performed before smoking cessation.SPSS 11.0.Fifty-one patients (60.8% smokers), 56.9% females, mean age 39.88 years old. Smokers initiated at an age of 15.77 years; the mean of cigarettes/day was 21.68. Significant differences in TNF-? serum levels between smokers and non-smokers were observed (P<.043). Differences did not reach significance for EBC. For tobacco consumption data, only age at smoking initiation and serum TNF-? levels had a correlation. A significant relation between TNF-? serum levels and forced expiratory volume in one second and forced vital capacity was found.Smokers show higher TNF-? levels in serum. Number of years of smoking has an influence on TNF-? levels. There is a modest correlation between pulmonary function and plasma TNF-? levels, but not for EBC.Copyright © 2011 Elsevier España, S.L. All rights reserved.

Keywords

Ciências biológicas iiGeneral medicineMedicina iMedicina iiMedicine (all)Medicine (miscellaneous)Medicine, general & internalOdontologíaSaúde coletiva

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MEDICINA CLINICA due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 65/155, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Medicine, General & Internal. Notably, the journal is positioned en el Cuartil Q3 para la agencia Scopus (SJR) en la categoría Medicine (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 1.56, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-04, the following number of citations:

  • WoS: 8

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Ensure healthy lives and promote well-being for all at all ages, with a probability of 88% according to the mBERT algorithm developed by Aurora University.