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Bellas, CAuthor

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November 19, 2015
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Clinicoepidemiologic characteristics, prognostic factors, and survival analysis of patients coinfected with human immunodeficiency virus and Leishmania in an area of Madrid, Spain

Publicated to:AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 58 (4): 436-443 - 1998-01-01 58(4), DOI: 10.4269/ajtmh.1998.58.436

Authors: Lopez-Velez, R; Perez-Molina, JA; Guerrero, A; Baquero, F; Villarrubia, J; Escribano, L; Bellas, C; Perez-Corral, F; Alvar, J

Affiliations

Biostatistics Department, Hospital Ramon y Cajal, Madrid, Spain - Author
Clinical Microbiology, Infectious Diseases Department, Hospital Ramon y Cajal, Madrid, Spain - Author
Hematology Department, Hospital Ramon Y Cajal, Madrid, Spain - Author
Instituto Carlos III, Madrid, Spain - Author
Microbiologia Clinica, Enfermedades Infecciosas, Hospital Ramon y Cajal, Apartado 31057, Madrid 28034, Spain - Author
Pathology Department, Hospital Ramón y Cajal, Madrid, Spain - Author
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Abstract

From 1987 to 1995, a retrospective case study was conducted at the Ramon y Cajal Hospital in Madrid, Spain, a public teaching hospital with 1,100 beds, to determine the clinicoepidemiologic characteristics, survival, and prognostic factors of patients with visceral leishmaniasis (VL) and human immunodeficiency virus (HIV) infection. The prevalence of VL in HIV+ patients compared with HIV- patients was studied. Epidemiologic, clinical, and parasitologic characteristics, as well as the effects of treatment, prognosis, and survival in 54 HIV+ patients (90 episodes) with VL were defined. Comparative survival studies among patients with and without acquired immunodeficiency syndrome (AIDS)-defining criteria and multivariate analysis of survival risk factors were performed. The prevalence of VL in patients with AIDS was much higher than in immunocompetent individuals. In spite of a good initial response to treatment for VL, 60.6% of the patients had relapsed by the end of one year. Mortality from the first episode was 18.5%, and 24% died in the first month after diagnosis of any VL episode. The mean survival of the 29 patients who died was 10.27 months. Survival in patients with and without AIDS at the time of the first episode of VL was compared at 30 months: 53.7% versus 20.5% (P = 0.00149). We found no significant difference (P = 0.24) in the survival of HIV+ patients who had died of VL without AIDS at the time of the first episode of VL compared with those of a control group of 413 dead patients with AIDS without VL. A diagnosis of AIDS at the time of the first episode of VL and thrombocytopenia were the only risk factors found related to survival. We conclude that in AIDS patients, VL is a recurrent disease that is highly prevalent and whose clinical course is modified by HIV.

Keywords

AdultAmphotericin b lipid complexAnemiaArticleControlled studyFemaleHumanHuman cellHuman immunodeficiency virus infectionHuman tissueHyperamylasemiaIntramuscular drug administrationIntravenous drug administrationLeishmaniasisLiver toxicityMajor clinical studyMaleMeglumine antimonateMortalityOral drug administrationPrognosisRecombinant gamma interferonSpainSubcutaneous drug administrationSurvival rateThrombocytopenia

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 1998, it was in position 1/12, thus managing to position itself as a Q1 (Primer Cuartil), in the category Tropical Medicine.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-05:

  • WoS: 90
  • Scopus: 123
  • Europe PMC: 61

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 71.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 71 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 15.