{rfName}
Ce

Indexed in

Altmetrics

Analysis of institutional authors

Fernandez-Cruz, AnaAuthor

Share

December 14, 2025
Publications
>
Article
No

Ceftazidime/avibactam for the treatment of bloodstream infection due to carbapenemase-producing Enterobacterales in onco-haematologic neutropenic patients (the TARZAN study)

Publicated to: Journal Of Antimicrobial Chemotherapy. 80 (6): 1673-1681 - 2025-04-11 80(6), DOI: 10.1093/jac/dkaf120

Authors:

Sastre-Escola, Enric; Ntziora, Fotinie; Chiurlo, Matteo; Martin-Davila, Pilar; Mikulska, Malgorzata; Albasanz-Puig, Adaia; Machado, Marina; Gutierrez-Villanueva, Andrea; Marquez-Gomez, Ignacio; Gasch-Blasi, Oriol; Sipsas, Nikolaos, V; Oltolini, Chiara; Fortun, Jesus; Ruiz-Camps, Isabel; Fernandez-Cruz, Ana; Pena, Marta; Laporte-Amargos, Julia; Bergas, Alba; Badia-Tejero, Ana Maria; Carratala, Jordi; Gudiol, Carlota
[+]

Affiliations

Hosp Duran i Reynals, Inst Catala Oncol ICO, Infect Dis Unit, IDIBELL, Lhospitalet De Llobregat, Spain - Author
Hosp Duran i Reynals, Inst Catala Oncol, Clin Hematol Dept, IDIBELL, Lhospitalet De Llobregat, Spain - Author
Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria, Clin Microbiol & Infect Dis Dept, Hosp Gregorio Maranon, Madrid, Spain - Author
Hosp Ramon & Cajal, Infect Dis Dept, Madrid, Spain - Author
Hosp Reg Univ Malaga, Infect Dis, Malaga, Andalucia, Spain - Author
Hosp Univ Vall dHebron, Infect Dis Dept, Barcelona, Spain - Author
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CIB, Madrid, Spain - Author
IRCCS Osped Policlin San Martino, Genoa, Italy - Author
IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Clin Infect Dis, Milan, Italy - Author
Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Infect Dis Unit, Dept Pathophysiol,Laiko Gen Hosp, Athens, Greece - Author
Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Propaedeut Internal Med 1, Athens, Greece - Author
Natl & Kapodistrian Univ Athens, Med Sch, Athens, Greece - Author
Univ Barcelona, Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Infect Dis Dept, Lhospitalet De Llobregat, Spain - Author
Univ Barcelona, Hosp Univ Parc Tauli, Inst Invest & Innovacio Parc Tauli l3PT CERCA, Infect Dis Dept, Sabadell, Spain - Author
Univ Genoa, Dept Hlth Sci DISSAL, Div Infect Dis, Genoa, Italy - Author
Univ Hosp Puerta de Hierro Majadahonda, Hlth Res Inst Puerta de Hierro Segovia de Arana, Internal Med Dept, Infect Dis Unit, Majadahonda 28222, Spain - Author
See more

Abstract

Objectives To assess the clinical features, antibiotic therapy and outcomes of carbapenemase-producing Enterobacterales bloodstream infection (CPE-BSI) in neutropenic patients with haematological malignancies treated with ceftazidime/avibactam.Methods We conducted a multicentre, international, retrospective, descriptive study of CPE-BSI episodes in neutropenic onco-haematological patients treated with ceftazidime/avibactam as empirical and/or targeted therapy (2017-2022).Results Of 54 episodes of CPE-BSI in haematological patients with neutropenia, more than half presented acute myeloid leukaemia (32, 59.5%). Klebsiella pneumoniae was the most frequently isolated pathogen (79.5%) and KPC the most prevalent carbapenemase (52%). The source of BSI was mainly endogenous (57.5%). Up to 11% presented with septic shock. Initial empirical antibiotic therapy was inadequate in 47% of cases, particularly monotherapy with meropenem or piperacillin/tazobactam. Ceftazidime/avibactam was administered empirically in 30% of patients and targeted in all episodes, mainly in combination with aminoglycosides, colistin or tigecycline. Nephrotoxicity occurred in 15% of patients, being attributed to aminoglycosides or colistin. Intensive care unit admission was required in 20% of cases. All-cause 7-day and 30-day case-fatality rates were 11% and 24%, respectively. Multivariate analysis showed that septic shock at BSI onset was an independent risk factor for 30-day mortality.Conclusions Ceftazidime/avibactam proved to be safe and efficacious for the treatment of CPE-BSI in this extremely high-risk population.
[+]

Keywords

AdultAgedAnti-bacterial agentsAvibactamAvibactam, ceftazidime drug combinationAzabicyclo compoundsBacteremiaBacterial proteinsBeta-lactamasesCancerCarbapenem-resistant enterobacteriaceaeCarbapenemaseCeftazidimeDefinitionDrug combinationsEnterobacteriaceae infectionsEpidemiologyFemaleHematologic neoplasmsHumansImpactKlebsiella pneumoniaeMaleMicrobial sensitivity testsMiddle agedMortalityNeutropeniaPneumoniaeResistant enterobacteriaceaeRetrospective studiesTherapyTreatment outcomeYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Infectious Diseases.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-03:

  • WoS: 2
  • Scopus: 2
[+]

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-03:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 10.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 20.
  • The number of mentions on the social network X (formerly Twitter): 26 (Altmetric).
[+]

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Greece; Italy.

[+]

Awards linked to the item

This study received funding from Pfizer. The company declares that it made no contribution towards the design and interpretation of the results of the study. The study was also supported by Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC) (CB21/13/00009) and Instituto de Salud Carlos III (Madrid, Spain).
[+]