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Analysis of institutional authors

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August 18, 2025
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From pathophysiology to novel approaches for obesity-associated hypertension

Publicated to: Clinical Kidney Journal. 18 (8): sfaf218- - 2025-08-01 18(8), DOI: 10.1093/ckj/sfaf218

Authors:

Kanbay, M; Yayci, E; Genc, C; Copur, S; Aktas, O; Sarafidis, P; Covic, A; Ortiz, A; Laffin, LJ
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Affiliations

Aristotle Univ Thessaloniki, Hippokrat Hosp, Dept Nephrol 1, Thessaloniki, Greece - Author
CI Parhon Univ Hosp, Dialysis & Renal Transplant Ctr, Nephrol Clin, Iasi, Romania - Author
Cleveland Clin Fdn, Cleveland Clin, Coordinating Ctr Clin Res, Cleveland, OH USA - Author
Cleveland Clin Fdn, Dept Cardiovasc Med, Sect Prevent Cardiol & Rehabil, Cleveland, OH USA - Author
IIS Fdn Jimenez Diaz, Madrid, Spain - Author
Koc Univ, Sch Med, Dept Med, Istanbul, Turkiye - Author
Koc Univ, Sch Med, Dept Med, Sect Nephrol, Istanbul, Turkiye - Author
Univ Autonoma Madrid, Dept Med, Madrid, Spain - Author
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Abstract

Obesity is a rapidly growing epidemic affecting >15% of the global adult population and has considerable clinical consequences and comorbidities, including hypertension, diabetes mellitus, cardiovascular and cerebrovascular diseases and chronic kidney disease. There is a strong association between obesity or body mass index and high blood pressure (BP) in epidemiological studies while the underlying pathophysiological events linking those conditions are not fully elucidated. Hypothetical mechanisms include a sedentary lifestyle and excess intake of processed foods that contribute to obesity, overactivation of the renin-angiotensin-aldosterone and sympathetic nervous systems, inflammation, altered adipokine homeostasis and the fatty kidney hypothesis involving adipose tissue accumulation in the renal sinus and perirenal space. There are multiple pharmacotherapeutic and surgical approaches for the management of obesity, including dual and triple agonist drugs targeting glucagon-like peptide-1, gastric inhibitory peptide and glucagon receptors and endoscopic bariatric procedures. Despite promising results with such therapeutic approaches in terms of body weight reduction and BP control, it is unclear whether such BP reduction may completely be attributable to weight loss. Confirmation of the adiposity dependence would lead to a major paradigm shift in our understanding of hypertension, potentially leading to a major shift in the causes of hypertension from primary hypertension to adiposity-dependent hypertension, leading to a shift from symptomatic treatment with antihypertensive medication to cause-focused treatment with weight loss medication. In this narrative review, the aim is to evaluate the potential pathophysiological mechanisms linking hypertension and obesity and the efficiency of potential therapeutic approaches on BP.
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Keywords

Adipose-tissueAdiposityBariatric surgeryBlood-pressureBody-mass indexCardiovascular risGlp-1 receptor agonistsGlucagon-like peptide-1HypertensionMineralocorticoid receptorObesitObesityWeight-lossY gastric bypass

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Clinical Kidney Journal due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 15/133, thus managing to position itself as a Q1 (Primer Cuartil), in the category Urology & Nephrology.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 36.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 36 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 5.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Greece; Oman; Turkey; United States of America.

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