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Analysis of institutional authors

Carrasco EAuthorFrancos-Quijorna IAuthorSoto-Heredero GAuthorGabandé-Rodríguez EAuthorMittelbrunn MAuthor

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August 4, 2025
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CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity.

Publicated to: Science immunology. 10 (110): eadv0985- - 2025-08-01 10(110), DOI: 10.1126/sciimmunol.adv0985

Authors:

Gómez de Las Heras MM; Carrasco E; Pérez-Manrique M; Inohara N; Delgado-Pulido S; Fernández-Almeida Á; Gálvez-Castaño MI; Francos-Quijorna I; Simó C; García-Cañas V; Escrig-Larena JI; Aranda JF; Soto-Heredero G; Gabandé-Rodríguez E; Blanco EM; Días-Almeida J; Núñez G; Mittelbrunn M
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Affiliations

Department of Biology, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), Madrid, Spain. - Author
Department of Genetics, Physiology, and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid (UCM), Madrid, Spain. - Author
Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA. - Author
Molecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. - Author
Tissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. - Author
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Abstract

Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the Tfamfl/flCd4Cre mouse model, we found that T cell failure compromised gut immunity leading to a decrease in T follicular cells and regulatory T cells (Treg cells) and an accumulation of highly proinflammatory and cytotoxic T cells. These alterations were associated with intestinal barrier disruption and gut dysbiosis. Microbiota depletion or adoptive transfer of total CD4 T cells or a Treg cell-enriched pool prevented gut barrier dysfunction and mitigated premature inflammaging and senescence, ultimately enhancing the health span in this mouse model. Thus, a competent CD4 T cell compartment is critical to ensure healthier aging by promoting host-microbiota mutualism and gut barrier integrity.
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Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Science immunology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 6/183, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology. Notably, the journal is positioned above the 90th percentile.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 23 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 79.
  • The number of mentions on the social network X (formerly Twitter): 97 (Altmetric).
  • The number of mentions in news outlets: 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Gómez de las Heras MM) and Last Author (MITTELBRUNN HERRERO, MARIA).

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