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Analysis of institutional authors

Gonzalez Beltran, DamianAuthor

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Prospective association between plasma amino acids and healthy aging in older adults.

Publicated to:Journal of internal medicine. (): - - 2025-06-12 (), DOI: 10.1111/joim.20105

Authors: González-Beltrán D; Yévenes-Briones H; Lana A; Cárdenas-Valladolid J; Ángel Salinero-Fort M; Rodríguez-Artalejo F; Lopez-Garcia E; Caballero FF

Affiliations

Department of Medicine, Universidad de Oviedo/ISPA, Oviedo, Spain. - Author
Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid, Madrid, Spain. - Author
Dirección General de Investigación y Docencia, Consejería de Sanidad de la Comunidad Autónoma de Madrid, Madrid, Spain. - Author
Subdirección General de Investigación Sanitaria, Consejería de Sanidad, Fundación de Investigación e Innovación Sanitaria de Atención Primaria, Madrid, Spain. - Author

Abstract

Most studies have compared plasma amino acids profiling across different age groups using a cross-sectional design, but no previous research has assessed the relationship between specific amino acid species and healthy aging. This study aims to explore the relationship between plasma concentrations of nine amino acids and healthy aging in an older Spanish population. This longitudinal study uses data from the Seniors-ENRICA 2 Spanish cohort, which comprises community-dwelling individuals aged 65 and older. Plasma amino acid concentrations were measured at baseline and after a 5-year follow-up period (n = 859). Healthy aging has been defined as the delay on the onset of chronic conditions, optimal physical functioning, and no cognitive impairment. Multilevel mixed effect logistic models were used to examine the prospective association proposed, after adjusting for age, sex, socioeconomic status, and lifestyle behaviors. The baseline mean age of the participants was 70.9 years (standard deviation [SD] = 4.0), and 51.6% were men. In the fully adjusted models, lower plasma concentrations of alanine [odds ratios per 1-SD increase (95% confidence interval) = 0.78 (0.72, 0.86)], isoleucine [0.70 (0.63, 0.78)], leucine [0.78 (0.71, 0.86)], and valine [0.79 (0.71, 0.86)] were prospectively associated with healthy aging (p-value < 0.001 in all cases). No significant associations were observed for glutamine, glycine, histidine, and aromatic amino acids. Lower concentrations of alanine and branched-chain amino acids were prospectively associated with healthy aging in the older population.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-19:

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.95.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (González-Beltrán D) and Last Author (Caballero FF).