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This research was funded by PID2019-106220RB100 granted by MICIU/AEI/10.13039/501100011033, and PID2022-137373OB-I00 granted by MICIU/AEI/10.13039/501100011033/FEDER, UE. JMH was supported by a grant FPI-UAM 2021 from Universidad Autonoma de Madrid (Molecular BioSciences PhD programme) . FAR was supported by Comunidad de Madrid grants PIPF-2022/SAL-GL25290. We would like to thank Raul Allende, Natalia Gil, Hind Makhloufi, Paula Gimenez, Alicia Garcia de Fernando and Miguel Lobete for their aid in the earlier experiments.

Analysis of institutional authors

Melones-Herrero, JorgeAuthorAguilar-Rico, FranciscoAuthorMatesanz, Ana IAuthorQuiroga, Adoracion GCorresponding Author

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Article

Antiproliferative activity in breast cancer cells of PtL2: A steroid-thiosemicarbazone platinum(II) complex

Publicated to:JOURNAL OF INORGANIC BIOCHEMISTRY 270 (): 112923- - 2025-09-01 270(), DOI: 10.1016/j.jinorgbio.2025.112923

Authors: Melones-Herrero, Jorge; Aguilar-Rico, Francisco; Matesanz, Ana I; Cales, Carmela; Sanchez-Perez, Isabel; Quiroga, Adoracion G

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Abstract

Breast cancer remains one of the most diagnosed cancers in women worldwide. Metallodrugs such as cisplatin are used in advanced stages and hormone independent tumors. We hereby report the synthesis and characterization of a new benzaldehyde thiosemicarbazone functionalized with an estradiol derivative, LH, and two metal complexes, PdCl2(LH) and PtL2. Both complexes were studied in solution showing enough stability to further perform antitumoral activity studies. The Pd(II) complex was discarded for its poor performance while PtL2 exhibited similar cytotoxic activity to cisplatin (CDDP) in estrogen receptor (+) and triple-negative breast cancer cells. Moreover, PtL2demonstrated reduced toxicity in healthy cell lines. It induced cell cycle arrest at the G0/G1 phase, distinguishing its mechanism of action from CDDP, which predominantly blocks cells in the S phase. Additionally, PtL2displayed a balanced intracellular distribution between the nucleus and cytoplasm, independent of estrogen receptor status. Further analysis revealed that PtL2dysregulated antioxidant enzyme expression, potentially disrupting redox homeostasis. These findings highlight PtL2's potential as a promising alternative to conventional platinum-based therapies, warranting further investigation into its molecular mechanisms and therapeutic applications.

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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 5.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 4 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.3.
  • The number of mentions on the social network X (formerly Twitter): 7 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MELONES HERRERO, JORGE) and Last Author (GOMEZ QUIROGA, ADORACION).

the authors responsible for correspondence tasks have been Sanchez-Perez, Isabel and GOMEZ QUIROGA, ADORACION.