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This research was supported by funding from the Sistema General de Regalias (SGR) of the Government of Colombia under the project titled "Investigacion, desarrollo, innovacion y transferencia de conocimiento para el procesamiento de la semilla de Sacha inchi en productos de valor agregado, como estrategia para mejorar la productividad del sector agroindustrial de la region Cundinamarca" [BPIN project number 2020000100169] and the grant funded by the MCIN/AEI/ERDF project titled "A way of making Europe" [PID 2022-138978OB-I00].

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April 28, 2025
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Antidiabetic and Immunomodulatory Properties of Peptide Fractions from Sacha Inchi Oil Press-Cake

Publicated to:FOODS 14 (7): 1231- - 2025-03-31 14(7), DOI: 10.3390/foods14071231

Authors: Torres-Sanchez, Erwin; Martinez-Villaluenga, Cristina; Paterson, Samuel; Hernandez-Ledesma, Blanca; Gutierrez, Luis-Felipe

Affiliations

CSIC, Inst Ciencia & Tecnol Alimentos & Nutr ICTAN, Madrid 28040, Spain - Author
UAM, CSIC, Inst Invest Ciencias Alimentac CIAL, Madrid 28049, Spain - Author
Univ Nacl Colombia, Fac Ciencias Agr, Bogota 111321, Colombia - Author
Univ Nacl Colombia, Inst Ciencia & Tecnol Alimentos ICTA, Bogota 111321, Colombia - Author

Abstract

Sacha inchi (SI) oil press-cake (SIPC), a by-product of the sacha inchi oil extraction process, represents a novel protein source with potential bioactive applications in food. In this study, a sacha inchi protein concentrate (SPC) derived from SIPC was subjected to simulated gastrointestinal digestion (SGID) using the INFOGEST 2.0 protocol. The resulting digests were fractionated by ultrafiltration (10 kDa), and the bioactive properties of the peptide fractions were evaluated. In vitro alpha-amylase inhibition was assessed, along with immunomodulatory markers (NO, IL-6, and TNF-alpha), in an ex vivo RAW 264.7 cell model. Both gastric and intestinal digests exhibited significant alpha-amylase inhibition (20-45%), with the

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Quality index

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 2 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    This work has been carried out with international collaboration, specifically with researchers from: Colombia.

    the author responsible for correspondence tasks has been Hernandez-Ledesma, Blanca.