Maintaining kidney health in aging societies: a JSN and ERA call to action.

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Maintaining kidney health in aging societies: a JSN and ERA call to action.

Publicated to:Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. (): - - 2025-04-10 (), DOI: 10.1093/ndt/gfaf068

Authors: Ortiz A; Kramer A; Rychlík I; Nangaku M; Yanagita M; Jager KJ; Caskey FJ; Stel VS; Kashihara N; Kuragano T; Suzuki Y; Takemoto Y; Yokoi H; Palladino G; Fliser D; Torra R; Wanner C

Affiliations

Department of Clinical Studies and Epidemiology, University Hospital Würzburg, Würzburg, Germany. - Author

Department of Medicine, Third Faculty of Medicine, Charles University, Prague, and University Hospital Kralovske Vinohrady, Prague, Czechia. - Author

Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain. - Author

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. - Author

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan. - Author

Department of Nephrology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan. - Author

Department of Urology, Osaka Metropolitan University, Osaka, Japan. - Author

Division of Kidney, Dialysis and Cardiology, Department of Internal Medicine, Hyogo Medical University, Hyogo, Japan. - Author

Division of Nephrology and Endocrinology, the University of Tokyo Graduate School of Medicine, Tokyo, Japan. - Author

ERA Headquarters, Parma, Italy. - Author

ERA Registry, Department of Medical Informatics, Amsterdam UMC location University, of Amsterdam, Amsterdam, The Netherlands. - Author

Kawasaki Medical School, Kurashiki, Japan. - Author

Nephrology Department, Fundació Puigvert, Institut de Recerca Sant Pau (IR-Sant Pau), Departament de Medicina, Universitat Autònoma de Barcelona, RICORS2040, Spai. - Author

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. BS8 2PS. - Author

Universität des Saarlandes, Homburg/Saar. - Author

Abstract

Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socioeconomic, and environmental burdens and need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying kidney aging will contribute to healthy aging as the kidneys have gerosuppressor functions. CKD has the highest negative impact on body aging among chronic non-communicable diseases. This should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular-kidney-metabolic health, geromedicine, gerosuppressors, and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology (JSN) and European Renal Association (ERA) call to action on Achieving Kidney Health in Aging/Aged Societies.

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There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (ORTIZ ARDUAN, ALBERTO) .

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