{rfName}
Mo

Indexed in

License and use

Citations

Altmetrics

Analysis of institutional authors

Share
Publications
>
Article

Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry.

Publicated to:Arthritis research & therapy. 27 (1): 4- - 2025-01-07 27(1), DOI: 10.1186/s13075-024-03468-6

Authors: Molina-Collada J; Domínguez-Álvaro M; Melero-González RB; de Miguel E; Silva-Díaz M; Valero Jaimes JA; González I; Sánchez Martín J; Narváez J; Calvet J; Casafont-Solé I; Román Ivorra JA; Labrada Arrabal S; Vasques Rocha M; Iñiguez CL; Bustabad Reyes MS; Campos Fernández C; Alcalde Villar M; Mas AJ; Blanco R;

Affiliations

- Author
Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain. molinacolladajuan@gmail.com. - Author
Research Unit, Sociedad Espanola de Reumatologia, Madrid, Spain. - Author
Rheumatology Department, Complejo Hospitalario Universitario de A Coruña, La Coruña, Spain. - Author
Rheumatology Department, Complexo Hospitalario Universitario de Ourense, Ourense, Spain. - Author
Rheumatology Department, Hospital del Mar, Barcelona, Spain. - Author
Rheumatology Department, Hospital Universitari Bellvitge. Hospitalet de Llobregat, Barcelona, Spain. - Author
Rheumatology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. - Author
Rheumatology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain. - Author
Rheumatology Department, Hospital Universitari Son Llàtzer, Palma de Mallorca, Spain. - Author
Rheumatology Department, Hospital Universitario Araba, Vitoria-Gasteiz, Spain. - Author
Rheumatology Department, Hospital Universitario de Canarias, La Laguna, Canarias, Spain. - Author
Rheumatology Department, Hospital Universitario de León, León, Spain. - Author
Rheumatology Department, Hospital Universitario Donosti, Donostia, Spain. - Author
Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain. - Author
Rheumatology Department, Hospital Universitario Marqués de Valdecilla. IDIVAL Immunopathology group, Santander, Spain. - Author
Rheumatology Department, Hospital Universitario Severo Ochoa Leganés, Madrid, Spain. - Author
Rheumatology Department, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA) (UAB), Sabadell, Spain. - Author
Rheumatology, Consorci Hospital General Universitari de València, Comunitat Valenciana, Spain. - Author
Rheumatology, Hospital Universitario Lucus Augusti, Galicia, Spain. - Author
See more

Abstract

To compare mortality rates between GCA patients and the general population in Spain, and to identify associated factors influencing mortality. ARTESER, a multicenter registry by the Spanish Society of Rheumatology, includes GCA patients from June 2013 to March 2019. Demographic, clinical, imaging, histological and mortality data were collected retrospectively. Only patients with at least one year of follow-up were included for analysis. The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. The factors influencing mortality were analyzed using Cox regression model. A total of 1200 patients with GCA were analyzed, with a mean (SD) follow-up of 2.18 (1.53) years. The overall five-year cumulative mortality rate (95%CI) was 37.86 (31.75-43.96) per 1000 patients/year. The cumulative mortality rate was significantly higher in males than females (59.04vs29.06; p<0.001). The age- and sex-adjusted cumulative mortality rate was similar to the Spanish general population (19.75vs20.72;p=0.559). In the multivariate analysis, older age (HR 1.11, 95%CI 1.073-1.142) and male sex (HR 1.775, 95%CI 1.214-2.594) were associated with increased mortality. Headache (HR 0.55, 95%CI 0.362-0.843) and high hemoglobin levels (HR 0.85, 95%CI 0.744-0.970) were protective factors against death. The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population. Older age and male sex appear to be associated with an increased risk of mortality, whereas headache and high hemoglobin levels might serve as protective factors against death.

Keywords

Quality index

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-01:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 2.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 2 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 27.63.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 19 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is: