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Analysis of institutional authors

Sanchez, SAuthor

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April 3, 2025
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GENTAMICIN FORMATION IN MICROMONOSPORA-PURPUREA - STIMULATORY EFFECT OF AMMONIUM

Publicated to: JOURNAL OF ANTIBIOTICS. 48 (6): 479-483 - 1995-06-01 48(6), DOI: 10.7164/antibiotics.48.479

Authors:

GONZALEZ, R; ISLAS, L; OBREGON, AM; ESCALANTE, L; SANCHEZ, S
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Affiliations

- Author

Abstract

The effect of ammonium on the fermentative production of gentamicin in Micromonospora purpurea has been studied using a chemically defined medium. Ammonium chloride concentrations ranging from 20 to 150 mM resulted in a proportional stimulation of growth and antibiotic formation. The use of other ammonium salts exerted a similar effect. Among the products of ammonium assimilation, glutamate and glutamine were able to exert the stimulatory effect. In addition, both amino acids reproduced the stimulation in resting cell systems of this microorganism and this result was not modified by the presence of chloramphenicol, eliminating a possible inductive action as the cause of this effect. The use of a glutamine synthetase inhibitor prevented antibiotic formation. This inhibition was reverted only by glutamine, suggesting that this amino acid was responsible of ammonium stimulation. Glutamine stimulation seems to be due to its ability to produce 2-deoxystreptamine and glucosamine, intermediates of the gentamicin biosynthetic pathway.
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Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-21:

  • WoS: 27
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-21:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 32 (PlumX).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (SANCHEZ FUENTES, SERGIO).

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