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March 31, 2025
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3D tumor cultures for drug resistance and screening development in clinical applications

Publicated to: Molecular Cancer. 24 (1): 93- - 2025-03-21 24(1), DOI: 10.1186/s12943-025-02281-2

Authors:

Peng, Z; Lv, XL; Sun, H; Zhao, LN; Huang, SG
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Affiliations

Autonomous Univ Madrid, Fac Sci, Spainish Natl Res Council, Consejo Super Invest Cient, Madrid 28049, Spain - Author
Fourth Mil Med Univ, Xijing Hosp, Dept Radiat Oncol, State Key Lab Holist Integrat Management Gastroint, Xian, Peoples R China - Author
Fourth Mil Med Univ, Xijing Hosp, Dept Radiat Oncol, Xian, Peoples R China - Author
Liuzhou Matern & Child Healthcare Hosp, Dept Clin Lab, Liuzhou, Guangxi, Peoples R China - Author
Liuzhou Tradit Chinese Med Hosp, Dept Clin Lab, Liuzhou, Guangxi, Peoples R China - Author
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Abstract

Tumor drug resistance presents a growing challenge in medical practice, particularly during anti-cancer therapies, where the emergence of drug-resistant cancer cells significantly complicates clinical treatment. In recent years, three-dimensional (3D) tumor culture technology, which more effectively simulates the in vivo physiological environment, has gained increasing attention in tumor drug resistance research and clinical applications. By mimicking the in vivo cellular microenvironment, 3D tumor culture technology not only recapitulates cell-cell interactions but also more faithfully reproduces the biological effects of therapeutic agents. Consequently, 3D tumor culture technology is emerging as a crucial tool in biomedical and clinical research. We summarize the benefits of 3D culture models and organoid technology, explore their application in the realm of drug resistance, drug screening, and personalized therapy, and discuss their potential application prospects and challenges in clinical transformation, with the aim of providing insights for optimizing cancer treatment strategies and advancing precision therapy.
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Keywords

3d tumor culture modelAnimalsAntineoplastic agentsCancerCancer resistanceCell culture techniquesCell culture techniques, three dimensionalCell-cultureDiscoveryDrug resistance, neoplasmDrug screeninDrug screeningDrug screening assays, antitumorFibroblastsHumansMedicineModelsNeoplasmsOrganoidsPatient-derived organoidsPrecision medicineSystemTumor microenvironment

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Molecular Cancer due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 4/320, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-14:

  • WoS: 18
  • Scopus: 16
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-14:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 39 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: China.

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Awards linked to the item

This work was supported by grants from the National Natural Science Foundation of China (Grant No. 82272941) and National Research founding of China(No.202108390033).
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