Increased Severity of Mycoplasma pneumoniae Infections in Spanish Children

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Increased Severity of Mycoplasma pneumoniae Infections in Spanish Children

Publicated to:PEDIATRIC INFECTIOUS DISEASE JOURNAL. 43 (12): 1113-1119 - 2024-12-01 43(12), DOI: 10.1097/INF.0000000000004461

Authors: Mendez-Echevarria, Ana; Calle-Miguel, Laura; Miralbes, Sheila; Barreiro-Perez, Sagrario; Afonso-Rodriguez, Olga; Soler-Simon, Jose Antonio; Espeleta-Fox, Ana; Jimenez-Jimenez, Ana Belen; Mendez-Sanchez, Alejandra; Rementeria-Radigales, Joseba Inaki; Guerrero-Del-Cueto, Fuensanta; Laveglia, Vanessa; Ortiz-Valentin, Irene; Gomez-Mera, Emilio; Fernandez-Puentes, Veronica; Rodriguez-Noriega-Bejar, Lucia; Bustillo, Matilde; Retuerta, Azucena; Fernandez-Cantalejo, Jose; Sanz-Rueda, Laura; Ibanez, Maria Mercedes; Berzosa, Arantxa; Fernandez-Ledesma, Berta; Alvaro, Alicia; Santamaria-Barrena, Teresa; Carazo-Gallego, Beatriz; Moraleda, Cinta; Calvo, Cristina

Affiliations

Autonomous Univ Madrid UAM, Pediat Dept, Madrid, Spain - Author

Fdn Jimenez Diaz, Madrid, Spain - Author

Hosp Clin San Carlos, Madrid, Spain - Author

Hosp Insular de Gran Canaria, Serv Reumatol, Las Palmas Gran Canaria, Spain - Author

Hosp Jerez de La Frontera, Jerez de la Frontera, Spain - Author

Hosp Univ 12 Octubre, Madrid, Spain - Author

Hosp Univ Basurto, Bilbao, Spain - Author

Hosp Univ Cabuenes, Gijon, Asturias, Spain - Author

Hosp Univ Cent Asturias, Oviedo, Spain - Author

Hosp Univ Gen Cataluna, Barcelona, Spain - Author

Hosp Univ Getafe, Getafe, Spain - Author

Hosp Univ Miguel Servet, Zaragoza, Spain - Author

Hosp Univ Nino Jesus, Madrid, Spain - Author

Hosp Univ Reg Malaga, Univ Malaga, Malaga, Spain - Author

Hosp Univ Rio Hortega, Valladolid, Spain - Author

Hosp Univ Toledo, Toledo, Spain - Author

Hosp Univ Torrecardenas, Almeria, Spain - Author

Hosp Univ Virgen Rocio, Seville, Spain - Author

Hosp Universitari Germans Trias i Pujol, Badalona, Spain - Author

Inst Hlth Res, IdiPAZ, Madrid, Spain - Author

Inst Salud Carlos III, CIBERINFEC, Madrid, Spain - Author

La Paz Hosp, Pediat Infect & Trop Dis Dept, Madrid, Spain - Author

Translat Res Network Pediat Infect Dis, Madrid, Spain - Author

Abstract

Background:Since the end of 2023, an elevated incidence and severity of Mycoplasma pneumoniae infections among children in Asia has been noted. Subsequently, this trend was observed in several European countries although limited data are currently available. We conducted a national study to delineate the ongoing M. pneumoniae outbreak in our country.Methods:A multicenter retrospective observational study was conducted across 32 hospitals in Spain, encompassing patients under 18 years old hospitalized for M. pneumoniae infection from January 2023 to March 2024. Infection was confirmed by positive polymerase chain reaction and/or by 2 serological tests.Results:A total of 623 children were included, with 79% of cases diagnosed in the final 3 months of the study period. Pneumonia was the most common diagnosis (87%). Respiratory symptoms were present in 97% of cases, with 62% requiring oxygen supplementation and 14% requiring admission to the pediatric intensive care unit (PICU). Risk factors for PICU admission included the presence of neurological symptoms, hypoxemia and a history of prematurity. Children admitted to the PICU exhibited significantly higher neutrophil counts upon admission.Conclusions:We have observed a notable increase in hospital admissions, including PICU support by up to 14%, due to M. pneumoniae infection in our country since November 2023, indicative of a more severe clinical course associated with this pathogen.

Keywords

<italic>mycoplasma pneumonia</italic>ChildCommunity-acquired infectioCommunity-acquired infectionMycoplasma pneumoniaPneumonia

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Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PEDIATRIC INFECTIOUS DISEASE JOURNAL due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 108/181, thus managing to position itself as a Q1 (Primer Cuartil), in the category Immunology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-05-25:

WoS: 3
Scopus: 3
Europe PMC: 2

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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (MENDEZ ECHEVARRIA, ANA MARIA) and Last Author (CALVO REY, CRISTINA).

the author responsible for correspondence tasks has been MENDEZ ECHEVARRIA, ANA MARIA.

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