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Grant support

A.G.Q., A.I.M. and D.F. acknowledge Spanish MINECO under grant PID2019-106220RB100 and PID2022-137373OB-I00. The authors acknowledge the Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU, RED2018-102471-T) as well as T.H. thanks the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement No. 897678.

Analysis of institutional authors

Fabra, DavidAuthorMatesanz, Ana IAuthorQuiroga, Adoracion GCorresponding Author

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December 2, 2024
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Proving the antimicrobial therapeutic activity on a new Copper-Thiosemicarbazone Complex

Publicated to:MOLECULAR PHARMACEUTICS. 21 (4): 1987-1997 - 2024-03-20 21(4), DOI: 10.1021/acs.molpharmaceut.3c01235

Authors: Fabra, David; Amariei, Georgiana; Ruiz-Camino, Daniel; Matesanz, Ana I; Rosal, Roberto; Quiroga, Adoracion G; Horcajada, Patricia; Hidalgo, Tania

Affiliations

IMDEA Energy Inst, Adv Porous Mat Unit APMU, Mostoles 28935, Madrid, Spain - Author
Univ Alcala, Dept Chem Engn, Alcala De Henares 28871, Spain - Author
Univ Autonoma Madrid, Dept Inorgan Chem, Madrid 28049, Spain - Author

Abstract

The misuse and overdose of antimicrobial medicines are fostering the emergence of novel drug-resistant pathogens, providing negative repercussions not only on the global healthcare system due to the rise of long-term or chronic patients and inefficient therapies but also on the world trade, productivity, and, in short, to the global economic growth. In view of these scenarios, novel action plans to constrain this antibacterial resistance are needed. Thus, given the proven antiproliferative tumoral and microbial features of thiosemicarbazone (TSCN) ligands, we have here synthesized a novel effective antibacterial copper-thiosemicarbazone complex, demonstrating both its solubility profile and complex stability under physiological conditions, along with their safety and antibacterial activity in contact with human cellular nature and two most predominant bacterial strains, respectively. A significant growth inhibition (17% after 20 h) is evidenced over time, paving the way toward an effective antibacterial therapy based on these copper-TSCN complexes.

Keywords

Anti-bacterial agentsAnti-infective agentsAntimicrobialBiocompatibilitBiocompatibilityCoordination complexesCopperCopper-thiosemicarbazone complexCu complexesDrugHumansOrganometallic compoundsPhysiological stabilityPhysiologicalstabilitySemicarbazonesThiosemicarbazone (tscn)Thiosemicarbazones

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal MOLECULAR PHARMACEUTICS due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 52/189, thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine, Research & Experimental.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-04:

  • WoS: 2
  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-04:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 13 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (FABRA ESCRIBANO, DAVID) .

the author responsible for correspondence tasks has been GOMEZ QUIROGA, ADORACION.